S 2337

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596873

CAS#: 67608-06-4

Description: S 2337 is a synthetic substrate used to estimate Factor X.


Chemical Structure

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S 2337
CAS# 67608-06-4

Theoretical Analysis

MedKoo Cat#: 596873
Name: S 2337
CAS#: 67608-06-4
Chemical Formula: C37H52N10O9
Exact Mass: 780.3919
Molecular Weight: 780.88
Elemental Analysis: C, 56.91; H, 6.71; N, 17.94; O, 18.44

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: S 2337; S-2337; S2337;

IUPAC/Chemical Name: piperidin-1-yl (S)-5-((2-(((S)-1-amino-5-guanidino-1-oxopentan-2-yl)(4-nitrophenyl)amino)-2-oxoethyl)amino)-4-((2S,3S)-2-benzamido-3-methylpentanamido)-5-oxopentanoate

InChi Key: WLORUVXXAABSGD-LTYDCPJSSA-N

InChi Code: InChI=1S/C37H52N10O9/c1-3-24(2)32(44-34(51)25-11-6-4-7-12-25)36(53)43-28(18-19-31(49)56-45-21-8-5-9-22-45)35(52)42-23-30(48)46(26-14-16-27(17-15-26)47(54)55)29(33(38)50)13-10-20-41-37(39)40/h4,6-7,11-12,14-17,24,28-29,32H,3,5,8-10,13,18-23H2,1-2H3,(H2,38,50)(H,42,52)(H,43,53)(H,44,51)(H4,39,40,41)/t24-,28-,29-,32-/m0/s1

SMILES Code: N=C(N)NCCC[C@@H](C(N)=O)N(C(CNC([C@H](CCC(ON1CCCCC1)=O)NC([C@H]([C@@H](C)CC)NC(C2=CC=CC=C2)=O)=O)=O)=O)C3=CC=C([N+]([O-])=O)C=C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 780.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Ahmad SS, Rawala R, Cheung WF, Stafford DW, Walsh PN. The role of the second growth-factor domain of human factor IXa in binding to platelets and in factor-X activation. Biochem J. 1995 Sep 1;310 ( Pt 2):427-31. Erratum in: Biochem J 1995 Dec 15;312(Pt 3):991. PubMed PMID: 7654178; PubMed Central PMCID: PMC1135912.

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4: Lindhout T, Baruch D, Schoen P, Franssen J, Hemker HC. Thrombin generation and inactivation in the presence of antithrombin III and heparin. Biochemistry. 1986 Oct 7;25(20):5962-9. PubMed PMID: 3790498.

5: Torano AE, Nakamura S, Levin J. Properties of the clotting enzyme responsible for endotoxin-mediated Limulus coagulation. Thromb Res. 1984 Jun 1;34(5):407-17. PubMed PMID: 6377572.

6: van Wijk EM, Smit JL. A chromogenic micro-assay for factor X-activity. Thromb Res. 1984 May 1;34(3):263-8. PubMed PMID: 6549615.

7: Gram J, Jespersen J, Sidelmann J. The assay of factor Xa on a centrifugal analyzer. Thromb Res. 1984 Jan 15;33(2):239-42. PubMed PMID: 6367133.

8: Laharrague P, Leleu T, Poignot JL, Cambus JP, Biermé R. [Monitoring anticoagulant treatment with the KEM-O-MAT 2HP autoanalyzer]. Nouv Rev Fr Hematol. 1983;25(2):107-12. French. PubMed PMID: 6866753.

9: Robijns P, Lijnen HR, Collen D. Amidolytic determination of Factor X in clinical plasma samples. Acta Clin Belg. 1983;38(5):289-94. PubMed PMID: 6659834.

10: Egberg N, Heedman PA. Simplified performance of amidolytic factor X assay. Thromb Res. 1982 Mar 1;25(5):437-40. PubMed PMID: 7071814.

11: Erskine JG, Walker ID, Davidson JF. Maintenance control of oral anticoagulant therapy by an automated chromogenic substrate assay of factor X. Clin Lab Haematol. 1982;4(2):179-86. PubMed PMID: 7116798.

12: van Wijk EM, Jeletich A, ten Cate JW. The application of an automated amidolytic factor X assay in oral anticoagulant treatment. Acta Chir Scand Suppl. 1982;509:117-22. PubMed PMID: 6962614.

13: van Wijk EM, Kahlé LH, ten Cate JW. A rapid manual chromogenic factor X assay. Thromb Res. 1981 Jun 1-25;22(5-6):681-6. PubMed PMID: 7302910.

14: van Wijk EM, Kahlé LH, Wiebosch M, ten Cate JW. Optimization of a mechanized amidolytic factor-X assay; influence of reaction conditions and reagents. Clin Chem. 1981 Jun;27(6):918-21. PubMed PMID: 7237773.

15: Conard J, Gradelet A, Samama M. [Estimation of Stuart factor using a synthetic substitute during oral anticoagulant treatment. Preliminary results (author's transl)]. Ann Biol Clin (Paris). 1981;39(2):81-3. French. PubMed PMID: 7258751.

16: Erskine JG, Walker ID, Davidson JF. Maintenance control of oral anticoagulant therapy by a chromogenic substrate assay for factor X. J Clin Pathol. 1980 May;33(5):445-8. PubMed PMID: 7400342; PubMed Central PMCID: PMC1146108.