WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 596863
CAS#: 57420-47-0
Description: Prumycin dihydrochloride is an antifungal antibiotic.
MedKoo Cat#: 596863
Name: Prumycin dihydrochloride
CAS#: 57420-47-0
Chemical Formula: C8H19Cl2N3O4
Exact Mass:
Molecular Weight: 292.15
Elemental Analysis: C, 32.89; H, 6.56; Cl, 24.27; N, 14.38; O, 21.90
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: Prumycin dihydrochloride; Prumycin HCl;
IUPAC/Chemical Name: (R)-2-amino-N-((2S,3R,4R)-4-amino-1,3-dihydroxy-5-oxopentan-2-yl)propanamide dihydrochloride
InChi Key: PKVUUDMKVLKVNA-CYBHTWLKSA-N
InChi Code: InChI=1S/C8H17N3O4.2ClH/c1-4(9)8(15)11-6(3-13)7(14)5(10)2-12;;/h2,4-7,13-14H,3,9-10H2,1H3,(H,11,15);2*1H/t4-,5+,6+,7-;;/m1../s1
SMILES Code: O=C[C@H](N)[C@H]([C@@H](NC([C@H](N)C)=O)CO)O.[H]Cl.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 292.15 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Tanaka K, Fukuda M, Amaki Y, Sakaguchi T, Inai K, Ishihara A, Nakajima H. Importance of prumycin produced by Bacillus amyloliquefaciens SD-32 in biocontrol against cucumber powdery mildew disease. Pest Manag Sci. 2017 Dec;73(12):2419-2428. doi: 10.1002/ps.4630. Epub 2017 Aug 29. PubMed PMID: 28560847.
2: Kumari M, Chandra S, Tiwari N, Subbarao N. High Throughput Virtual Screening to Identify Novel natural product Inhibitors for MethionyltRNA-Synthetase of Brucella melitensis. Bioinformation. 2017 Jan 20;13(1):8-16. doi: 10.6026/97320630013008. eCollection 2017. PubMed PMID: 28479744; PubMed Central PMCID: PMC5405087.
3: Otoguro K, Ishiyama A, Kobayashi M, Sekiguchi H, Izuhara T, Sunazuka T, Tomoda H, Yamada H, Omura S. In vitro and in vivo antimalarial activities of a carbohydrate antibiotic, prumycin, against drug-resistant strains of Plasmodia. J Antibiot (Tokyo). 2004 Jun;57(6):400-2. PubMed PMID: 15323130.
4: Hamada M, Ikeda T, Manabe M, Gomi S, Kondo S, Takeuchi T, Umezawa H. Prumycin produced by Bacillus cereus. J Antibiot (Tokyo). 1983 Jan;36(1):86. PubMed PMID: 6432762.
5: Okubo S, Morimoto M, Mineura K, Marumo H, Omura S. Studies on antitumor activity of prumycin. IV. Effect of prumycin on mouse immune system. J Antibiot (Tokyo). 1980 Feb;33(2):231-5. PubMed PMID: 7380733.
6: Okubo S, Nakamura N, Morimoto M, Mineura K, Marumo H, Omura S. Studies on antitumor activity of prumycin. II. Studies on distribution and excretion of prumycin. J Antibiot (Tokyo). 1980 Feb;33(2):221-5. PubMed PMID: 7380732.
7: Okubo S, Nakamura N, Morimoto M, Mineura K, Marumo H, Omura S. Studies on antitumor activity of prumycin. III. Mode of action of prumycin on HeLa S-3 cells. J Antibiot (Tokyo). 1980 Feb;33(2):226-30. PubMed PMID: 6155368.
8: Okubo S, Nakamura N, Ito K, Marumo H, Tanaka M, Omura S. Antitumor activity of prumycin. J Antibiot (Tokyo). 1979 Apr;32(4):347-54. PubMed PMID: 468722.
9: Hasegawa A, Aritake N, Kiso M. Synthesis of prumycin and related compounds. Carbohydr Res. 1976 Dec;52:137-49. PubMed PMID: 1016984.
10: Hasegawa A, Aritake N, Kiso M. A new synthesis of prumycin. Carbohydr Res. 1976 Oct;51(1):C10-C12. PubMed PMID: 1000523.
11: Schwartz JL, Katagiri M, Omura S, Tishler M. The mechanism of prumycin action. J Antibiot (Tokyo). 1974 Jun;27(6):379-85. PubMed PMID: 4854949.
12: Omura S, Katagiri M, Atsumi K, Hata T, Jakubowski AA, Springs EB, Tishler M. Structure of prumycin. J Chem Soc Perkin 1. 1974;0(14):1627-31. PubMed PMID: 4472323.
13: Hata T, Omura S, Katagiri M, Atsumi K, Awaya J. A new antifungal antibiotic, prumycin. J Antibiot (Tokyo). 1971 Dec;24(12):900-1. PubMed PMID: 5140535.
