Alprenolol hydrochloride, (S)-

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596847

CAS#: 15132-12-4

Description: Alprenolol hydrochloride, (S)- is a nonselective β-blocker and a serotonin 5HT1A receptor antagonist.

Chemical Structure

Alprenolol hydrochloride, (S)-
CAS# 15132-12-4

Theoretical Analysis

MedKoo Cat#: 596847
Name: Alprenolol hydrochloride, (S)-
CAS#: 15132-12-4
Chemical Formula: C15H24ClNO2
Exact Mass: 285.1496
Molecular Weight: 285.81
Elemental Analysis: C, 63.04; H, 8.46; Cl, 12.40; N, 4.90; O, 11.20

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Alprenolol hydrochloride, (S)-; Alprenolol HCl, (S)-; L-Alloprenalol hydrochloride;

IUPAC/Chemical Name: 1-(2-allylphenoxy)-3-(isopropylamino)propan-2-ol hydrochloride


InChi Code: InChI=1S/C15H23NO2.ClH/c1-4-7-13-8-5-6-9-15(13)18-11-14(17)10-16-12(2)3;/h4-6,8-9,12,14,16-17H,1,7,10-11H2,2-3H3;1H


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 285.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

1: Soave M, Cseke G, Hutchings CJ, Brown AJH, Woolard J, Hill SJ. A monoclonal antibody raised against a thermo-stabilised β(1)-adrenoceptor interacts with extracellular loop 2 and acts as a negative allosteric modulator of a sub-set of β(1)-adrenoceptors expressed in stable cell lines. Biochem Pharmacol. 2018 Jan;147:38-54. doi: 10.1016/j.bcp.2017.10.015. Epub 2017 Nov 2. PubMed PMID: 29102678; PubMed Central PMCID: PMC5770334.

2: Veinberg SL, Johnston KE, Jaroszewicz MJ, Kispal BM, Mireault CR, Kobayashi T, Pruski M, Schurko RW. Natural abundance (14)N and (15)N solid-state NMR of pharmaceuticals and their polymorphs. Phys Chem Chem Phys. 2016 Jun 29;18(26):17713-30. doi: 10.1039/c6cp02855a. PubMed PMID: 27314503.

3: Thanawala VJ, Valdez DJ, Joshi R, Forkuo GS, Parra S, Knoll BJ, Bouvier M, Leff P, Bond RA. β-Blockers have differential effects on the murine asthma phenotype. Br J Pharmacol. 2015 Oct;172(20):4833-46. doi: 10.1111/bph.13253. Epub 2015 Oct 13. PubMed PMID: 26211486; PubMed Central PMCID: PMC4621987.

4: Sistik P, Urinovska R, Brozmanova H, Kacirova I, Silhan P, Lemr K. Fast simultaneous LC/MS/MS determination of 10 active compounds in human serum for therapeutic drug monitoring in psychiatric medication. Biomed Chromatogr. 2016 Feb;30(2):217-24. doi: 10.1002/bmc.3538. Epub 2015 Jul 26. PubMed PMID: 26094602.

5: Evans SE, Davies P, Lubben A, Kasprzyk-Hordern B. Determination of chiral pharmaceuticals and illicit drugs in wastewater and sludge using microwave assisted extraction, solid-phase extraction and chiral liquid chromatography coupled with tandem mass spectrometry. Anal Chim Acta. 2015 Jul 2;882:112-26. doi: 10.1016/j.aca.2015.03.039. Epub 2015 Mar 28. PubMed PMID: 26043098.

6: Liu X, Ma L, Li HH, Huang B, Li YX, Tao YZ, Ma L. β-Arrestin-biased signaling mediates memory reconsolidation. Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):4483-8. doi: 10.1073/pnas.1421758112. Epub 2015 Mar 23. Erratum in: Proc Natl Acad Sci U S A. 2015 May 26;112(21):E2847. PubMed PMID: 25831532; PubMed Central PMCID: PMC4394255.

7: Ghanem A, Ahmed M, Ishii H, Ikegami T. Immobilized β-cyclodextrin-based silica vs polymer monoliths for chiral nano liquid chromatographic separation of racemates. Talanta. 2015 Jan;132:301-14. doi: 10.1016/j.talanta.2014.09.006. Epub 2014 Sep 16. PubMed PMID: 25476312.

8: Kong XD, Yuan S, Li L, Chen S, Xu JH, Zhou J. Engineering of an epoxide hydrolase for efficient bioresolution of bulky pharmaco substrates. Proc Natl Acad Sci U S A. 2014 Nov 4;111(44):15717-22. doi: 10.1073/pnas.1404915111. Epub 2014 Oct 20. PubMed PMID: 25331869; PubMed Central PMCID: PMC4226085.

9: Bai Q, Shao Y, Pan D, Zhang Y, Liu H, Yao X. Search for β2 adrenergic receptor ligands by virtual screening via grid computing and investigation of binding modes by docking and molecular dynamics simulations. PLoS One. 2014 Sep 17;9(9):e107837. doi: 10.1371/journal.pone.0107837. eCollection 2014. PubMed PMID: 25229694; PubMed Central PMCID: PMC4168136.

10: Lebedeva MV, Prokhorova AF, Shapovalova EN, Shpigun OA. Clarithromycin as a chiral selector for enantioseparation of basic compounds in nonaqueous capillary electrophoresis. Electrophoresis. 2014 Oct;35(19):2759-64. doi: 10.1002/elps.201400135. Epub 2014 Aug 19. PubMed PMID: 25100556.

11: Ribeiro AR, Santos LH, Maia AS, Delerue-Matos C, Castro PM, Tiritan ME. Enantiomeric fraction evaluation of pharmaceuticals in environmental matrices by liquid chromatography-tandem mass spectrometry. J Chromatogr A. 2014 Oct 10;1363:226-35. doi: 10.1016/j.chroma.2014.06.099. Epub 2014 Jul 8. PubMed PMID: 25047821.

12: Hsieh ML, Chau LK, Hon YS. Single-step approach for fabrication of vancomycin-bonded silica monolith as chiral stationary phase. J Chromatogr A. 2014 Sep 5;1358:208-16. doi: 10.1016/j.chroma.2014.07.003. Epub 2014 Jul 9. PubMed PMID: 25047820.

13: Ma Y, Zhang H, Rahman ZU, Wang W, Li X, Chen H, Chen X. Sensitive enantioanalysis of β-blockers via field-amplified sample injection combined with water removal in microemulsion electrokinetic chromatography. Electrophoresis. 2014 Oct;35(19):2772-7. doi: 10.1002/elps.201400008. Epub 2014 Jun 20. PubMed PMID: 24798241.

14: Ahmed M, Ghanem A. Chiral β-cyclodextrin functionalized polymer monolith for the direct enantioselective reversed phase nano liquid chromatographic separation of racemic pharmaceuticals. J Chromatogr A. 2014 Jun 6;1345:115-27. doi: 10.1016/j.chroma.2014.04.023. Epub 2014 Apr 16. PubMed PMID: 24786651.

15: Qiang YG, Liao YH, Zhang XP, Li J, Huang Z. Modulation of β-adrenergic receptor in rat lung after gamma irradiation. J Xray Sci Technol. 2014;22(2):165-73. doi: 10.3233/XST-140417. PubMed PMID: 24699345.

16: Ahmed M, Ghanem A. Enantioselective nano liquid chromatographic separation of racemic pharmaceuticals: a facile one-pot in situ preparation of lipase-based polymer monoliths in capillary format. Chirality. 2014 Nov;26(11):754-63. doi: 10.1002/chir.22290. Epub 2014 Mar 6. PubMed PMID: 24604679.

17: Ogrodowczyk M, Marciniec B. Comparative analysis of selected beta-blockers. Acta Pol Pharm. 2013 Sep-Oct;70(5):779-86. PubMed PMID: 24147355.

18: Bai Q, Zhang Y, Ban Y, Liu H, Yao X. Computational study on the different ligands induced conformation change of β2 adrenergic receptor-Gs protein complex. PLoS One. 2013 Jul 29;8(7):e68138. doi: 10.1371/journal.pone.0068138. Print 2013. PubMed PMID: 23922653; PubMed Central PMCID: PMC3726664.

19: Kuznetsova LA, Plesneva SA, Sharova TS, Pertseva MN, Shpakov AO. [Regulation of adenylyl cyclase signaling system by insulin, biogenic amines, and glucagon at their separate and combined action in the muscle membranes of the mollusc Anodonta cygnea]. Zh Evol Biokhim Fiziol. 2013 Mar-Apr;49(2):111-7. Russian. PubMed PMID: 23789396.

20: Bussy U, Delaforge M, El-Bekkali C, Ferchaud-Roucher V, Krempf M, Tea I, Galland N, Jacquemin D, Boujtita M. Acebutolol and alprenolol metabolism predictions: comparative study of electrochemical and cytochrome P450-catalyzed reactions using liquid chromatography coupled to high-resolution mass spectrometry. Anal Bioanal Chem. 2013 Jul;405(18):6077-85. doi: 10.1007/s00216-013-7050-7. Epub 2013 May 23. PubMed PMID: 23700103.