WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 596844
CAS#: 38455-85-5
Description: l-alpha-Noracetylmethadol is discontinued (DEA controlled substance).
MedKoo Cat#: 596844
Name: l-alpha-Noracetylmethadol
CAS#: 38455-85-5
Chemical Formula: C20H27NO
Exact Mass: 297.2093
Molecular Weight: 297.44
Elemental Analysis: C, 80.76; H, 9.15; N, 4.71; O, 5.38
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: l-alpha-Noracetylmethadol; alpha-Noracetylmethadol, l;
IUPAC/Chemical Name: 6-(methylamino)-4,4-diphenylheptan-3-ol
InChi Key: KYHAUJGXNUJCTC-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H27NO/c1-4-19(22)20(15-16(2)21-3,17-11-7-5-8-12-17)18-13-9-6-10-14-18/h5-14,16,19,21-22H,4,15H2,1-3H3
SMILES Code: OC(CC)C(C1=CC=CC=C1)(CC(NC)C)C2=CC=CC=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 297.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
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2: Schrott LM, Sparber SB. Suppressed fever and hypersensitivity responses in chicks prenatally exposed to opiates. Brain Behav Immun. 2004 Nov;18(6):515-25. PubMed PMID: 15331122.
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4: Nanovskaya TN, Deshmukh SV, Miles R, Burmaster S, Ahmed MS. Transfer of L-alpha-acetylmethadol (LAAM) and L-alpha-acetyl-N-normethadol (norLAAM) by the perfused human placental lobule. J Pharmacol Exp Ther. 2003 Jul;306(1):205-12. Epub 2003 Apr 3. PubMed PMID: 12676878.
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9: Oda Y, Kharasch ED. Metabolism of levo-alpha-Acetylmethadol (LAAM) by human liver cytochrome P450: involvement of CYP3A4 characterized by atypical kinetics with two binding sites. J Pharmacol Exp Ther. 2001 Apr;297(1):410-22. PubMed PMID: 11259570.
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12: Vaupel DB, Jasinski DR. l-alpha-Acetylmethadol, l-alpha-acetyl-N-normethadol and l-alpha-acetyl-N,N-dinormethadol: comparisons with morphine and methadone in suppression of the opioid withdrawal syndrome in the dog. J Pharmacol Exp Ther. 1997 Nov;283(2):833-42. PubMed PMID: 9353405.
13: Wilkins DG, Valdez AS, Krueger GG, Rollins DE. Quantitative analysis of l-alpha-acetylmethadol, l-alpha-acetyl-N-normethadol, and l-alpha-acetyl-N,N-dinormethadol in human hair by positive ion chemical ionization mass spectrometry. J Anal Toxicol. 1997 Oct;21(6):420-6. PubMed PMID: 9323520.
14: Moody DE, Crouch DJ, Sakashita CO, Alburges ME, Minear K, Schulthies JE, Foltz RL. A gas chromatographic-positive ion chemical ionization-mass spectrometric method for the determination of I-alpha-acetylmethadol (LAAM), norLAAM, and dinorLAAM in plasma, urine, and tissue. J Anal Toxicol. 1995 Oct;19(6):343-51. PubMed PMID: 8926727.
15: Borzelleca JF, Egle JL Jr, Harris LS, Belleville JA. Toxicological evaluation of mu-agonists. Part II: Assessment of toxicity following 30 days of repeated oral dosing of male and female rats with levo-alpha-noracetylmethadol HCl (NorLAAM). J Appl Toxicol. 1995 Sep-Oct;15(5):339-55. PubMed PMID: 8666717.
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18: Vernadakis A, Gibson A. Neurotoxicity of opiates during brain development: in vivo and in vitro studies. Prog Clin Biol Res. 1985;163C:245-53. PubMed PMID: 2986161.
19: James RC, Freeman RW, Harbison RD. L-alpha-acetylmethadol-induced tissue alterations in mice. Drug Chem Toxicol. 1984;7(1):91-112. PubMed PMID: 6723548.
20: Roerig DL, Dahl RR, Dawson CA, Wang RI. Uptake of l-alpha-acetylmethadol (LAAM) and its analgesically active metabolites, nor-LAAM and dinor-LAAM, in the isolated perfused rat lung. Drug Metab Dispos. 1983 Sep-Oct;11(5):411-6. PubMed PMID: 6138224.
