Aminooxy-PEG3-thiol HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 571928

CAS#: 1200365-63-4 (free base)

Description: Aminooxy-PEG3-thiol HCl salt is an Aminooxy PEG Linker. Aminooxy-PEG can be used in bioconjugation. It reacts with an aldehyde to form an oxime bond. If a reductant is used, it will form a hydroxylamine linkage. PEG Linkers may be useful in the development of antibody drug conjugates and drug delivery methods.


Chemical Structure

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Aminooxy-PEG3-thiol HCl
CAS# 1200365-63-4 (free base)

Theoretical Analysis

MedKoo Cat#: 571928
Name: Aminooxy-PEG3-thiol HCl
CAS#: 1200365-63-4 (free base)
Chemical Formula: C8H21Cl2NO4S
Exact Mass:
Molecular Weight: 298.219
Elemental Analysis: C, 32.22; H, 7.10; Cl, 23.77; N, 4.70; O, 21.46; S, 10.75

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Aminooxy-PEG3-thiol HCl salt

IUPAC/Chemical Name: 2-(2-(2-(2-(aminooxy)ethoxy)ethoxy)ethoxy)ethane-1-thiol dihydrochloride

InChi Key: RIDCHCVNPSGRPM-UHFFFAOYSA-N

InChi Code: InChI=1S/C8H19NO4S.2ClH/c9-13-6-5-11-2-1-10-3-4-12-7-8-14;;/h14H,1-9H2;2*1H

SMILES Code: SCCOCCOCCOCCON.[H]Cl.[H]Cl

Appearance: Solid powder

Purity: >90% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 298.219 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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6: Rashidian M, Kumarapperuma SC, Gabrielse K, Fegan A, Wagner CR, Distefano MD. Simultaneous dual protein labeling using a triorthogonal reagent. J Am Chem Soc. 2013 Nov 6;135(44):16388-96. doi: 10.1021/ja403813b. Epub 2013 Oct 17. PubMed PMID: 24134212; PubMed Central PMCID: PMC3873327.

7: Hardy JG, Lin P, Schmidt CE. Biodegradable hydrogels composed of oxime crosslinked poly(ethylene glycol), hyaluronic acid and collagen: a tunable platform for soft tissue engineering. J Biomater Sci Polym Ed. 2015;26(3):143-61. doi: 10.1080/09205063.2014.975393. PubMed PMID: 25555089.