Capnoidine

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596729

CAS#: 485-50-7

Description: Capnoidine is a potential new anti-inflammatory drug lead candidate for diseases where current standard-of-care often fails and is associated with major side effects. It also validates the traditional uses of C. dubia against inflammatory conditions and underlines the value of pursuing bioactive compounds derived from traditionally used ethnobotanical medicines.


Chemical Structure

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Capnoidine
CAS# 485-50-7

Theoretical Analysis

MedKoo Cat#: 596729
Name: Capnoidine
CAS#: 485-50-7
Chemical Formula: C20H17NO6
Exact Mass: 367.1056
Molecular Weight: 367.35
Elemental Analysis: C, 65.39; H, 4.66; N, 3.81; O, 26.13

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Capnoidine; l-Adlumidine; l-Capnoidine; (-)-Adlumidine;

IUPAC/Chemical Name: (R)-6-((R)-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-[1,3]dioxolo[4,5-e]isobenzofuran-8(6H)-one

InChi Key: IYGYMKDQCDOMRE-QZTJIDSGSA-N

InChi Code: InChI=1S/C20H17NO6/c1-21-5-4-10-6-14-15(25-8-24-14)7-12(10)17(21)18-11-2-3-13-19(26-9-23-13)16(11)20(22)27-18/h2-3,6-7,17-18H,4-5,8-9H2,1H3/t17-,18-/m1/s1

SMILES Code: O=C1O[C@@H]([C@@H]2N(C)CCC3=CC4=C(OCO4)C=C23)C5=CC=C(OCO6)C6=C51

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 367.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Shepherd C, Giacomin P, Navarro S, Miller C, Loukas A, Wangchuk P. A medicinal plant compound, capnoidine, prevents the onset of inflammation in a mouse model of colitis. J Ethnopharmacol. 2018 Jan 30;211:17-28. doi: 10.1016/j.jep.2017.09.024. Epub 2017 Sep 21. PubMed PMID: 28942135.

2: Niu X, Li W, Xu H, Liu X, Qi L. Simultaneous quantification of 11 isoquinoline alkaloids in Corydalis impatiens (Pall.) Fisch by HPLC. J Sep Sci. 2013 Jul;36(13):2090-5. doi: 10.1002/jssc.201300036. Epub 2013 Jun 10. PubMed PMID: 23610009.

3: Wangchuk P, Keller PA, Pyne SG, Willis AC, Kamchonwongpaisan S. Antimalarial alkaloids from a Bhutanese traditional medicinal plant Corydalis dubia. J Ethnopharmacol. 2012 Aug 30;143(1):310-3. doi: 10.1016/j.jep.2012.06.037. Epub 2012 Jul 14. PubMed PMID: 22796506.

4: Preininger V, Thakur RS, Santavý F. Isolation and chemistry of alkaloids from plants of the family Papaveraceae LXVII: Corydalis cava (L.) Sch. et K. (C. tuberosa DC). J Pharm Sci. 1976 Feb;65(2):294-6. PubMed PMID: 1255467.