Naxagolide free base

We are open as normal during COVID-19 pandemic. Order online, same day shipping out from North Carolina, USA

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 562938

CAS#: 88058-88-2 (free base)

Description: Naxagolide is a sustained release formulation of a naphthoxazine compound with selective D-2 dopamine receptor agonism. It is a dopamine agonist and an Antiparkinsonian.


Price and Availability

Size Price Shipping out time Quantity
Inquire bulk and customized quantity

Pricing updated 2020-09-20. Prices are subject to change without notice.

Naxagolide free base is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 562938
Name: Naxagolide free base
CAS#: 88058-88-2 (free base)
Chemical Formula: C15H21NO2
Exact Mass: 247.1572
Molecular Weight: 247.33
Elemental Analysis: C, 72.84; H, 8.56; N, 5.66; O, 12.94


Related CAS #: 99705-65-4 (HCl)   88058-88-2 (free base)   100935-99-7 (S-isomer HCl)    

Synonym: Naxagolide; PHNO; Dopazinol; (+)-Propyl-hexahydro-naphtho-oxazin;

IUPAC/Chemical Name: (4aR,10bR)-4-Propyl-2,3,4a,5,6,10b-hexahydrobenzo[h][1,4]benzoxazin-9-ol

InChi Key: JCSREICEMHWFAY-HUUCEWRRSA-N

InChi Code: InChI=1S/C15H21NO2/c1-2-7-16-8-9-18-15-13-10-12(17)5-3-11(13)4-6-14(15)16/h3,5,10,14-15,17H,2,4,6-9H2,1H3/t14-,15-/m1/s1

SMILES Code: OC1=CC=C2CC[C@@]3([H])N(CCC)CCO[C@]3([H])C2=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Payer D, Balasubramaniam G, Boileau I. What is the role of the D3 receptor in addiction? A mini review of PET studies with [(11)C]-(+)-PHNO. Prog Neuropsychopharmacol Biol Psychiatry. 2014 Jul 3;52:4-8. doi: 10.1016/j.pnpbp.2013.08.012. Epub 2013 Aug 30. Review. PubMed PMID: 23999545.

2: Iversen L, Foster AC, Hill RG, Iversen SD, Kemp JA, Leeson PD, Rupniak NM, Saywell K, Tricklebank MD, Williams BJ. Neurotoxin-related research: from the laboratory to the clinic. Ann N Y Acad Sci. 1992 May 11;648:207-18. Review. PubMed PMID: 1353328.

3: Goetz CG, Diederich NJ. Dopaminergic agonists in the treatment of Parkinson's disease. Neurol Clin. 1992 May;10(2):527-40. Review. PubMed PMID: 1350052.

4: Obeso JA, Luquin MR, Vaamonde J, Grandas F, Pastor MA, Artieda J, Martínez-Lage JM. [Continuous dopaminergic stimulation in Parkinson disease]. Neurologia. 1987 Sep-Oct;2(5):227-34. Review. Spanish. PubMed PMID: 2908545.