WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596715

CAS#: 215874-86-5

Description: L-822179 or α5IA is a selective inverse agonist for Α5 subtype of GABAA receptor with a higher intrinsic activity at the A5 subtype than other drugs. α5IA enhances cognition in laboratory animals without being proconvulsant or anxiogenic. α5IA acts as an "alcohol antagonist," markedly reducing the amnesic effect of alcohol and partially attenuating sedation, similar to Ro15-4513, but without the anxiogenic effect. α5IA offers promise as a tool to study cognitive disorders, memory function, and treatment of alcohol-related disorders.

Chemical Structure

CAS# 215874-86-5

Theoretical Analysis

MedKoo Cat#: 596715
Name: L-822179
CAS#: 215874-86-5
Chemical Formula: C17H14N8O2
Exact Mass: 362.124
Molecular Weight: 362.35
Elemental Analysis: C, 56.35; H, 3.89; N, 30.92; O, 8.83

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: L-822179; L 822179; L822179; L-822,179; L 822,179; L822,179; alpha 5IA;

IUPAC/Chemical Name: 5-methyl-3-(6-((1-methyl-1H-1,2,3-triazol-4-yl)methoxy)-[1,2,4]triazolo[3,4-a]phthalazin-3-yl)isoxazole


InChi Code: InChI=1S/C17H14N8O2/c1-10-7-14(22-27-10)16-20-19-15-12-5-3-4-6-13(12)17(21-25(15)16)26-9-11-8-24(2)23-18-11/h3-8H,9H2,1-2H3


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 362.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

1: Lesaffre E. Noninferiority Clinical Trials: The Good, the Bad, and the Ugly. Semin Liver Dis. 2018 May;38(2):97-102. doi: 10.1055/s-0038-1655777. Epub 2018 Jun 5. PubMed PMID: 29871016.

2: Zhang S, Huang Q, Wang Q, Wang Q, Cao X, Zhao L, Xu N, Zhuge Z, Mao J, Fu X, Liu R, Wilcox CS, Patzak A, Li L, Lai EY. Enhanced Renal Afferent Arteriolar Reactive Oxygen Species and Contractility to Endothelin-1 Are Associated with Canonical Wnt Signaling in Diabetic Mice. Kidney Blood Press Res. 2018 May 30;43(3):860-871. doi: 10.1159/000490334. [Epub ahead of print] PubMed PMID: 29870994.

3: Saranya K, Sundaramanickam A, Shekhar S, Meena M, Sathishkumar RS, Balasubramanian T. Biosorption of multi-heavy metals by coral associated phosphate solubilising bacteria Cronobacter muytjensii KSCAS2. J Environ Manage. 2018 Jun 2;222:396-401. doi: 10.1016/j.jenvman.2018.05.083. [Epub ahead of print] PubMed PMID: 29870968.

4: Xu Y, Wu P, Feng P, Guo W, Yang W, Shuai C. Interfacial reinforcement in a poly-l-lactic acid/mesoporous bioactive glass scaffold via polydopamine. Colloids Surf B Biointerfaces. 2018 May 29;170:45-53. doi: 10.1016/j.colsurfb.2018.05.065. [Epub ahead of print] PubMed PMID: 29870952.

5: Lewis C, Lennon AM, Eudoxie G, Umaharan P. Genetic variation in bioaccumulation and partitioning of cadmium in Theobroma cacao L. Sci Total Environ. 2018 Jun 2;640-641:696-703. doi: 10.1016/j.scitotenv.2018.05.365. [Epub ahead of print] PubMed PMID: 29870946.

6: Douw G, Huisman-de Waal G, van Zanten ARH, van der Hoeven JG, Schoonhoven L. Surgical ward nurses' responses to worry: An observational descriptive study. Int J Nurs Stud. 2018 May 21;85:90-95. doi: 10.1016/j.ijnurstu.2018.05.009. [Epub ahead of print] PubMed PMID: 29870923.

7: Yu X, Chen J, Li Y, Liu H, Hou C, Zeng Q, Cui Y, Zhao L, Li P, Zhou Z, Pang S, Tang S, Tian K, Zhao Q, Dong L, Xu C, Zhang X, Zhang S, Liu L, Wang A. Threshold effects of moderately excessive fluoride exposure on children's health: A potential association between dental fluorosis and loss of excellent intelligence. Environ Int. 2018 Jun 2;118:116-124. doi: 10.1016/j.envint.2018.05.042. [Epub ahead of print] PubMed PMID: 29870912.

8: Muangchinda C, Rungsihiranrut A, Prombutara P, Soonglerdsongpha S, Pinyakong O. 16S metagenomic analysis reveals adaptability of a mixed-PAH-degrading consortium isolated from crude oil-contaminated seawater to changing environmental conditions. J Hazard Mater. 2018 May 29;357:119-127. doi: 10.1016/j.jhazmat.2018.05.062. [Epub ahead of print] PubMed PMID: 29870896.

9: Riisom M, Gammelgaard B, Lambert IH, Stürup S. Development and validation of an ICP-MS method for quantification of total carbon and platinum in cell samples and comparison of open-vessel and microwave-assisted acid digestion methods. J Pharm Biomed Anal. 2018 May 24;158:144-150. doi: 10.1016/j.jpba.2018.05.038. [Epub ahead of print] PubMed PMID: 29870891.

10: Wu Y, Hu Y, Haiyan Z, YunLin W, Xincong K, Dongbo L. Xiaokeping-induced autophagy protects pancreatic β-cells against apoptosis under high glucose stress. Biomed Pharmacother. 2018 Jun 2;105:407-412. doi: 10.1016/j.biopha.2018.05.147. [Epub ahead of print] PubMed PMID: 29870888.

11: Yun H, Lim S, Kim YX, Lee Y, Lee S, Lee D, Park K, Sung J. Diurnal changes in CN metabolism and response of rice seedlings to UV-B radiation. J Plant Physiol. 2018 Mar 13;228:66-74. doi: 10.1016/j.jplph.2018.02.007. [Epub ahead of print] PubMed PMID: 29870880.

12: Xiong JL, Li J, Wang HC, Zhang CL, Naeem MS. Fullerol improves seed germination, biomass accumulation, photosynthesis and antioxidant system in Brassica napus L. under water stress. Plant Physiol Biochem. 2018 May 26;129:130-140. doi: 10.1016/j.plaphy.2018.05.026. [Epub ahead of print] PubMed PMID: 29870864.

13: Li F, Sun C, Li X, Yu X, Luo C, Shen Y, Qu S. The effect of graphene oxide on adventitious root formation and growth in apple. Plant Physiol Biochem. 2018 May 30;129:122-129. doi: 10.1016/j.plaphy.2018.05.029. [Epub ahead of print] PubMed PMID: 29870863.

14: van der Does Y, Limper M, Jie KE, Schuit SCE, Jansen H, Pernot N, van Rosmalen J, Poley MJ, Ramakers C, Patka P, van Gorp ECM, Rood PPM. Procalcitonin-guided antibiotic therapy in patients with fever in a general emergency department population: a multicenter noninferiority randomized clinical trial (HiTEMP study). Clin Microbiol Infect. 2018 Jun 2. pii: S1198-743X(18)30442-7. doi: 10.1016/j.cmi.2018.05.011. [Epub ahead of print] PubMed PMID: 29870855.

15: Miailhes P, Hartig-Lavie K, Virlogeux V, Pradat P, Diakite M, Uhres AC, Zoulim F, Sarda MN. Benefit of direct-acting antiviral therapy for hepatitis C virus (HCV) in monoinfected and HIV-HCV coinfected patients with mixed cryoglobulinemia. Clin Microbiol Infect. 2018 Jun 2. pii: S1198-743X(18)30452-X. doi: 10.1016/j.cmi.2018.05.019. [Epub ahead of print] PubMed PMID: 29870852.

16: Wathsala RHGR, Franzellitti S, Scaglione M, Fabbri E. Styrene impairs normal embryo development in the Mediterranean mussel (Mytilus galloprovincialis). Aquat Toxicol. 2018 May 30;201:58-65. doi: 10.1016/j.aquatox.2018.05.026. [Epub ahead of print] PubMed PMID: 29870829.

17: Lim CLL, Chua AQ, Teo JQM, Cai Y, Lee W, Kwa AL. Importance of Control Groups When Delineating Antibiotic Use as Risk Factors for Carbapenem-Resistance, Extreme-Drug and Pan-Drug Resistance in Acinetobacter baumannii and Pseudomonas aeruginosa: A Systematic Review and Meta-Analysis. Int J Infect Dis. 2018 Jun 2. pii: S1201-9712(18)34427-8. doi: 10.1016/j.ijid.2018.05.017. [Epub ahead of print] PubMed PMID: 29870795.

18: Abdel Fadeel DA, Muneer G, Elsharif AM, Al-Jameel SS, Mohamed HH, Youssef TE. Improved photodynamic efficacy of thiophenyl sulfonated zinc phthalocyanine loaded in lipid nano-carriers as new formulation for hepatocellular carcinoma cancer cells. Photodiagnosis Photodyn Ther. 2018 Jun 2. pii: S1572-1000(18)30091-7. doi: 10.1016/j.pdpdt.2018.06.003. [Epub ahead of print] PubMed PMID: 29870793.

19: Yu J, Shin J, Park M, Seydametova E, Jung SM, Seo JH, Kweon DH. Engineering of α-1,3-fucosyltransferases for production of 3-fucosyllactose in Escherichia coli. Metab Eng. 2018 Jun 2. pii: S1096-7176(17)30465-2. doi: 10.1016/j.ymben.2018.05.021. [Epub ahead of print] PubMed PMID: 29870790.

20: Sarasquete C, Úbeda-Manzanaro M, Ortiz-Delgado JB. Toxicity and non-harmful effects of the soya isoflavones, genistein and daidzein, in embryos of the zebrafish, Danio rerio. Comp Biochem Physiol C Toxicol Pharmacol. 2018 Jun 2. pii: S1532-0456(18)30077-2. doi: 10.1016/j.cbpc.2018.05.012. [Epub ahead of print] PubMed PMID: 29870789.