L 743310

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596701

CAS#: 187724-86-3

Description: L 743310 is a neurokinin-1 receptor antagonist.

Chemical Structure

L 743310
CAS# 187724-86-3

Theoretical Analysis

MedKoo Cat#: 596701
Name: L 743310
CAS#: 187724-86-3
Chemical Formula: C30H33BrF6N4O2
Exact Mass:
Molecular Weight: 675.51
Elemental Analysis: C, 53.34; H, 4.92; Br, 11.83; F, 16.87; N, 8.29; O, 4.74

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: L 743310; L-743310; L743310; L-743,310; L 743,310; L743,310;

IUPAC/Chemical Name: 4-(3-(5-(3,5-bis(trifluoromethyl)phenyl)-1-(1H-indol-3-yl)-3-oxopentan-2-yl)ureido)-1-methylquinuclidin-1-ium bromide


InChi Code: InChI=1S/C30H32F6N4O2.BrH/c1-40-11-8-28(9-12-40,10-13-40)39-27(42)38-25(16-20-18-37-24-5-3-2-4-23(20)24)26(41)7-6-19-14-21(29(31,32)33)17-22(15-19)30(34,35)36;/h2-5,14-15,17-18,25,37H,6-13,16H2,1H3,(H-,38,39,42);1H

SMILES Code: O=C(NC12CC[N+](CC2)(C)CC1)NC(C(CCC3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)=O)CC4=CNC5=C4C=CC=C5.[Br-]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 675.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Laird JM, Roza C, De Felipe C, Hunt SP, Cervero F. Role of central and peripheral tachykinin NK1 receptors in capsaicin-induced pain and hyperalgesia in mice. Pain. 2001 Feb 1;90(1-2):97-103. PubMed PMID: 11166975.

2: Robichaud A, Tattersall FD, Choudhury I, Rodger IW. Emesis induced by inhibitors of type IV cyclic nucleotide phosphodiesterase (PDE IV) in the ferret. Neuropharmacology. 1999 Feb;38(2):289-97. PubMed PMID: 10218871.

3: Tattersall FD, Rycroft W, Francis B, Pearce D, Merchant K, MacLeod AM, Ladduwahetty T, Keown L, Swain C, Baker R, Cascieri M, Ber E, Metzger J, MacIntyre DE, Hill RG, Hargreaves RJ. Tachykinin NK1 receptor antagonists act centrally to inhibit emesis induced by the chemotherapeutic agent cisplatin in ferrets. Neuropharmacology. 1996;35(8):1121-9. PubMed PMID: 9121615.