WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 596687
CAS#: 159565-60-3
Description: L 738372 is a quinazolinone; a non-nucleoside inhibitor of HIV-1 reverse transcriptase.
MedKoo Cat#: 596687
Name: L 738372
CAS#: 159565-60-3
Chemical Formula: C18H15N3O
Exact Mass: 289.1215
Molecular Weight: 289.33
Elemental Analysis: C, 74.72; H, 5.23; N, 14.52; O, 5.53
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: L 738372; L-738372; L738372; L-738,372; L 738,372; L738,372;
IUPAC/Chemical Name: (S)-4-cyclopropyl-4-(pyridin-2-ylethynyl)-3,4-dihydroquinazolin-2(1H)-one
InChi Key: GRKPBOOXGCBIQK-GOSISDBHSA-N
InChi Code: InChI=1S/C18H15N3O/c22-17-20-16-7-2-1-6-15(16)18(21-17,13-8-9-13)11-10-14-5-3-4-12-19-14/h1-7,12-13H,8-9H2,(H2,20,21,22)/t18-/m1/s1
SMILES Code: O=C1NC2=C(C=CC=C2)[C@@](C#CC3=NC=CC=C3)(C4CC4)N1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 289.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Wang T, Grinberg N, Bicker G, Tway P, Thompson K. High-performance liquid chromatographic separation of an HIV-1 reverse transcriptase inhibitor and its enantiomer. J Chromatogr A. 1996 Jul 12;738(2):290-4. PubMed PMID: 8696508.
2: Prueksaritanont T, Balani SK, Dwyer LM, Ellis JD, Kauffman LR, Varga SL, Pitzenberger SM, Theoharides AD. Species differences in the metabolism of a potent HIV-1 reverse transcriptase inhibitor L-738,372. In vivo and in vitro studies in rats, dogs, monkeys, and human. Drug Metab Dispos. 1995 Jul;23(7):688-95. PubMed PMID: 7587955.
3: Carroll SS, Stahlhut M, Geib J, Olsen DB. Inhibition of HIV-1 reverse transcriptase by a quinazolinone and comparison with inhibition by pyridinones. Differences in the rates of inhibitor binding and in synergistic inhibition with nucleoside analogs. J Biol Chem. 1994 Dec 23;269(51):32351-7. PubMed PMID: 7528214.
