WAY-208466 HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 562933

CAS#: 1207064-61-6 (HCl)

Description: WAY-208466 2HCl is a selective serotonin 5-HT6 receptor agonist.

Chemical Structure

WAY-208466 HCl
CAS# 1207064-61-6 (HCl)

Theoretical Analysis

MedKoo Cat#: 562933
Name: WAY-208466 HCl
CAS#: 1207064-61-6 (HCl)
Chemical Formula: C17H20Cl2FN3O2S
Exact Mass: 347.1104
Molecular Weight: 420.3244
Elemental Analysis: C, 48.58; H, 4.80; Cl, 16.87; F, 4.52; N, 10.00; O, 7.61; S, 7.63

Price and Availability

Size Price Availability Quantity
5.0mg USD 260.0 2 Weeks
10.0mg USD 440.0 2 Weeks
25.0mg USD 790.0 2 Weeks
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Related CAS #: 633304-27-5 (free base)   1207064-61-6 (HCl)    

Synonym: WAY-208466 2HCl; WAY 208466 2HCl; WAY208466 2HCl; WAY-208466 dihydrochloride; WAY 208466 dihydrochloride; WAY208466 dihydrochloride;

IUPAC/Chemical Name: 2-[3-(3-Fluorophenyl)sulfonylpyrrolo[2,3-b]pyridin-1-yl]-N,N-dimethylethanamine dihydrochloride


InChi Code: InChI=1S/C17H18FN3O2S.2ClH/c1-20(2)9-10-21-12-16(15-7-4-8-19-17(15)21)24(22,23)14-6-3-5-13(18)11-14;;/h3-8,11-12H,9-10H2,1-2H3;2*1H

SMILES Code: O=S(C1=CN(CCN(C)C)C2=NC=CC=C21)(C3=CC=CC(F)=C3)=O.[H]Cl.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 420.3244 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Pineda-Farias JB, Barragán-Iglesias P, Valdivieso-Sánchez A, Rodríguez-Silverio J, Flores-Murrieta FJ, Granados-Soto V, Rocha-González HI. Spinal 5-HT(4) and 5-HT(6) receptors contribute to the maintenance of neuropathic pain in rats. Pharmacol Rep. 2017 Oct;69(5):916-923. doi: 10.1016/j.pharep.2017.04.001. Epub 2017 Apr 4. PubMed PMID: 28628851.

2: Brodsky M, Lesiak AJ, Croicu A, Cohenca N, Sullivan JM, Neumaier JF. 5-HT(6) receptor blockade regulates primary cilia morphology in striatal neurons. Brain Res. 2017 Apr 1;1660:10-19. doi: 10.1016/j.brainres.2017.01.010. Epub 2017 Jan 10. PubMed PMID: 28087224; PubMed Central PMCID: PMC5392252.

3: Zhang YM, Zhang L, Wang Y, Sun YN, Guo Y, Du CX, Zhang J, Yao L, Yu SQ, Liu J. Activation and blockade of prelimbic 5-HT6 receptors produce different effects on depressive-like behaviors in unilateral 6-hydroxydopamine-induced Parkinson's rats. Neuropharmacology. 2016 Nov;110(Pt A):25-36. doi: 10.1016/j.neuropharm.2016.07.014. Epub 2016 Jul 14. PubMed PMID: 27424103.

4: Wang HY, Lu CW, Lin TY, Kuo JR, Wang SJ. WAY208466 inhibits glutamate release at hippocampal nerve terminals. Eur J Pharmacol. 2016 Jun 15;781:117-27. doi: 10.1016/j.ejphar.2016.04.010. Epub 2016 Apr 8. PubMed PMID: 27068148.

5: Liu KC, Li JY, Tan HH, Du CX, Xie W, Zhang YM, Ma WL, Zhang L. Serotonin₆ receptors in the dorsal hippocampus regulate depressive-like behaviors in unilateral 6-hydroxydopamine-lesioned Parkinson's rats. Neuropharmacology. 2015 Aug;95:290-8. doi: 10.1016/j.neuropharm.2015.03.031. Epub 2015 Apr 9. PubMed PMID: 25863121.

6: Monti JM, Jantos H, Schechter LE. The effects of systemic and local microinjection into the central nervous system of the selective serotonin 5-HT6 receptor agonist WAY-208466 on sleep and wakefulness in the rat. Behav Brain Res. 2013 Jul 15;249:65-74. doi: 10.1016/j.bbr.2013.04.024. Epub 2013 Apr 24. PubMed PMID: 23624323.

7: Carr GV, Schechter LE, Lucki I. Antidepressant and anxiolytic effects of selective 5-HT6 receptor agonists in rats. Psychopharmacology (Berl). 2011 Feb;213(2-3):499-507. doi: 10.1007/s00213-010-1798-7. Epub 2010 Mar 9. PubMed PMID: 20217056; PubMed Central PMCID: PMC2910165.

8: Schechter LE, Lin Q, Smith DL, Zhang G, Shan Q, Platt B, Brandt MR, Dawson LA, Cole D, Bernotas R, Robichaud A, Rosenzweig-Lipson S, Beyer CE. Neuropharmacological profile of novel and selective 5-HT6 receptor agonists: WAY-181187 and WAY-208466. Neuropsychopharmacology. 2008 May;33(6):1323-35. Epub 2007 Jul 11. PubMed PMID: 17625499.