WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 596682
CAS#: 150220-81-8
Description: L 705589 is a water-soluble semisynthetic pneumocandin Bo derivative.
MedKoo Cat#: 596682
Name: L 705589
CAS#: 150220-81-8
Chemical Formula: C52H85N9O17
Exact Mass: 1107.6063
Molecular Weight: 1108.29
Elemental Analysis: C, 56.35; H, 7.73; N, 11.37; O, 24.54
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Synonym: L 705589; L-705589; L705589;
IUPAC/Chemical Name: N-((2R,6S,9S,11R,12R,14aS,16R,20S,23S,25aS)-20-((R)-3-amino-1-hydroxy-3-oxopropyl)-12-(2-aminoethoxy)-23-((1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl)-2,11,16-trihydroxy-6-((R)-1-hydroxyethyl)-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl)-10,12-dimethyltetradecanamide
InChi Key: ZCNYHIMDCYQWRN-OPIWARQOSA-N
InChi Code: InChI=1S/C52H85N9O17/c1-5-27(2)20-28(3)12-10-8-6-7-9-11-13-40(69)55-34-23-38(67)50(78-19-18-53)59-48(74)36-22-33(65)26-61(36)52(77)42(37(66)24-39(54)68)57-49(75)43(45(71)44(70)30-14-16-31(63)17-15-30)58-47(73)35-21-32(64)25-60(35)51(76)41(29(4)62)56-46(34)72/h14-17,27-29,32-38,41-45,50,62-67,70-71H,5-13,18-26,53H2,1-4H3,(H2,54,68)(H,55,69)(H,56,72)(H,57,75)(H,58,73)(H,59,74)/t27?,28?,29-,32-,33-,34+,35+,36+,37-,38-,41+,42+,43+,44+,45+,50-/m1/s1
SMILES Code: CCC(CC(CCCCCCCCC(N[C@H]1C[C@@H](O)[C@@H](OCCN)NC([C@@H]2C[C@@H](O)CN2C([C@H]([C@H](O)CC(N)=O)NC([C@H]([C@H](O)[C@@H](O)c3ccc(O)cc3)NC([C@@H]4C[C@@H](O)CN4C([C@H]([C@H](O)C)NC1=O)=O)=O)=O)=O)=O)=O)C)C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 1108.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Schmatz DM, Powles MA, McFadden D, Nollstadt K, Bouffard FA, Dropinski JF, Liberator P, Andersen J. New semisynthetic pneumocandins with improved efficacies against Pneumocystis carinii in the rat. Antimicrob Agents Chemother. 1995 Jun;39(6):1320-3. PubMed PMID: 7574523; PubMed Central PMCID: PMC162734.
2: Abruzzo GK, Flattery AM, Gill CJ, Kong L, Smith JG, Krupa D, Pikounis VB, Kropp H, Bartizal K. Evaluation of water-soluble pneumocandin analogs L-733560, L-705589, and L-731373 with mouse models of disseminated aspergillosis, candidiasis, and cryptococcosis. Antimicrob Agents Chemother. 1995 May;39(5):1077-81. PubMed PMID: 7625792; PubMed Central PMCID: PMC162686.
3: Bartizal K, Scott T, Abruzzo GK, Gill CJ, Pacholok C, Lynch L, Kropp H. In vitro evaluation of the pneumocandin antifungal agent L-733560, a new water-soluble hybrid of L-705589 and L-731373. Antimicrob Agents Chemother. 1995 May;39(5):1070-6. PubMed PMID: 7625791; PubMed Central PMCID: PMC162685.
