L 708286

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596669

CAS#: 119720-81-9

Description: L 708286 is a peptide-based phenethylcarbamoyldifluoromethylene compound; slow-binding inhibitor of human leucocyte elastase (HLE).


Chemical Structure

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L 708286
CAS# 119720-81-9

Theoretical Analysis

MedKoo Cat#: 596669
Name: L 708286
CAS#: 119720-81-9
Chemical Formula: C25H34F2N4O5
Exact Mass: 508.25
Molecular Weight: 508.560
Elemental Analysis: C, 59.04; H, 6.74; F, 7.47; N, 11.02; O, 15.73

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: L 708286; L-708286; L708286; DFKi;

IUPAC/Chemical Name: (S)-1-(acetyl-L-alanyl)-N-((S)-5,5-difluoro-2-methyl-4,6-dioxo-6-(phenethylamino)hexan-3-yl)pyrrolidine-2-carboxamide

InChi Key: DIDRITFKGCLDSK-VDGAXYAQSA-N

InChi Code: InChI=1S/C25H34F2N4O5/c1-15(2)20(21(33)25(26,27)24(36)28-13-12-18-9-6-5-7-10-18)30-22(34)19-11-8-14-31(19)23(35)16(3)29-17(4)32/h5-7,9-10,15-16,19-20H,8,11-14H2,1-4H3,(H,28,36)(H,29,32)(H,30,34)/t16-,19-,20-/m0/s1

SMILES Code: O=C(N[C@@H](C(C)C)C(C(F)(F)C(NCCC1=CC=CC=C1)=O)=O)[C@H]2N(C([C@H](C)NC(C)=O)=O)CCC2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 508.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Zhang L, Song L, Terracina G, Liu Y, Pramanik B, Parker E. Biochemical characterization of the gamma-secretase activity that produces beta-amyloid peptides. Biochemistry. 2001 Apr 24;40(16):5049-55. PubMed PMID: 11305921.

2: Masek BB, Merchant A, Matthew JB. Molecular skins: a new concept for quantitative shape matching of a protein with its small molecule mimics. Proteins. 1993 Oct;17(2):193-202. PubMed PMID: 8265566.

3: Knight WB, Swiderek KM, Sakuma T, Calaycay J, Shively JE, Lee TD, Covey TR, Shushan B, Green BG, Chabin R, et al. Electrospray ionization mass spectrometry as a mechanistic tool: mass of human leucocyte elastase and a beta-lactam-derived E-I complex. Biochemistry. 1993 Mar 2;32(8):2031-5. PubMed PMID: 8095408.