L 691678

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596658

CAS#: 144210-49-1

Description: L 691678 is a potent inhibitor of leukotriene biosynthesis.


Chemical Structure

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L 691678
CAS# 144210-49-1

Theoretical Analysis

MedKoo Cat#: 596658
Name: L 691678
CAS#: 144210-49-1
Chemical Formula: C36H30IN5O5S
Exact Mass: 771.1012
Molecular Weight: 771.63
Elemental Analysis: C, 56.04; H, 3.92; I, 16.45; N, 9.08; O, 10.37; S, 4.15

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: L 691678; L-691678; L691678;

IUPAC/Chemical Name: 3-(3-((4-azidophenyl)sulfonyl)-1-(4-iodobenzyl)-5-(quinolin-2-ylmethoxy)-1H-indol-2-yl)-2,2-dimethylpropanoic acid

InChi Key: YDONNKKRJRSVEQ-UHFFFAOYSA-N

InChi Code: InChI=1S/C36H30IN5O5S/c1-36(2,35(43)44)20-33-34(48(45,46)29-16-13-26(14-17-29)40-41-38)30-19-28(47-22-27-12-9-24-5-3-4-6-31(24)39-27)15-18-32(30)42(33)21-23-7-10-25(37)11-8-23/h3-19H,20-22H2,1-2H3,(H,43,44)

SMILES Code: O=C(O)C(C)(C)CC(N1CC2=CC=C(I)C=C2)=C(S(=O)(C3=CC=C(N=[N+]=[N-])C=C3)=O)C4=C1C=CC(OCC5=NC6=CC=CC=C6C=C5)=C4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 771.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Vickers PJ, Adam M, Charleson S, Coppolino MG, Evans JF, Mancini JA. Identification of amino acid residues of 5-lipoxygenase-activating protein essential for the binding of leukotriene biosynthesis inhibitors. Mol Pharmacol. 1992 Jul;42(1):94-102. PubMed PMID: 1635556.

2: Mancini JA, Prasit P, Coppolino MG, Charleson P, Leger S, Evans JF, Gillard JW, Vickers PJ. 5-Lipoxygenase-activating protein is the target of a novel hybrid of two classes of leukotriene biosynthesis inhibitors. Mol Pharmacol. 1992 Feb;41(2):267-72. PubMed PMID: 1538707.