AG 392

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 591346

CAS#: 158018-62-3

Description: AG 392 is a biochemical.

Chemical Structure

img
AG 392
CAS# 158018-62-3
Instruction

Theoretical Analysis

MedKoo Cat#: 591346
Name: AG 392
CAS#: 158018-62-3
Chemical Formula: C24H24N6O4S
Exact Mass: 492.16
Molecular Weight: 492.550
Elemental Analysis: C, 58.52; H, 4.91; N, 17.06; O, 12.99; S, 6.51

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: AG 392; AG-392; AG392

IUPAC/Chemical Name: 2,4-Quinazolinediamine, 6-((ethyl((4-((4-nitrophenyl)sulfonyl)phenyl)methyl)amino)methyl)-

InChi Key: RHILSNIKHKKVCT-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H24N6O4S/c1-2-29(15-17-5-12-22-21(13-17)23(25)28-24(26)27-22)14-16-3-8-19(9-4-16)35(33,34)20-10-6-18(7-11-20)30(31)32/h3-13H,2,14-15H2,1H3,(H4,25,26,27,28)

SMILES Code: NC1=NC(N)=C2C=C(CN(CC)CC3=CC=C(S(=O)(C4=CC=C([N+]([O-])=O)C=C4)=O)C=C3)C=CC2=N1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 492.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Zhuo ZJ, Zhang R, Zhang J, Zhu J, Yang T, Zou Y, He J, Xia H. Associations between lncRNA MEG3 polymorphisms and neuroblastoma risk in Chinese children. Aging (Albany NY). 2018 Mar 27;10(3):481-491. doi: 10.18632/aging.101406. PubMed PMID: 29615542; PubMed Central PMCID: PMC5892699.

2: Rehman S, Saba N, Naz M, Ahmed P, Munir S, Sajjad S, Tabassum S, Naseem L. Single-Nucleotide Polymorphisms of FAS and FASL Genes and Risk of Idiopathic Aplastic Anemia. Immunol Invest. 2018 Apr 3:1-8. doi: 10.1080/08820139.2018.1458106. [Epub ahead of print] PubMed PMID: 29611722.

3: Crow RS, Lohman MC, Pidgeon D, Bruce ML, Bartels SJ, Batsis JA. Frailty Versus Stopping Elderly Accidents, Deaths and Injuries Initiative Fall Risk Score: Ability to Predict Future Falls. J Am Geriatr Soc. 2018 Mar;66(3):577-583. doi: 10.1111/jgs.15275. Epub 2018 Feb 10. PubMed PMID: 29427525; PubMed Central PMCID: PMC5933526.

4: Rafighdoost H, Hashemi M, Asadi H, Bahari G. Association of single nucleotide polymorphisms in WNT genes with the risk of nonsyndromic cleft lip with or without cleft palate. Congenit Anom (Kyoto). 2018 Jan 22. doi: 10.1111/cga.12271. [Epub ahead of print] PubMed PMID: 29356097.

5: Lu GY, Wang WX. Trace metals and macroelements in mussels from Chinese coastal waters: National spatial patterns and normalization. Sci Total Environ. 2018 Jun 1;626:307-318. doi: 10.1016/j.scitotenv.2018.01.018. Epub 2018 Feb 19. PubMed PMID: 29353779.

6: Gillingham AK. At the ends of their tethers! How coiled-coil proteins capture vesicles at the Golgi. Biochem Soc Trans. 2018 Feb 19;46(1):43-50. doi: 10.1042/BST20170188. Epub 2017 Dec 22. Review. PubMed PMID: 29273618.

7: Jena AB, Olenski AR, Molitor D, Miller N. Association between rainfall and diagnoses of joint or back pain: retrospective claims analysis. BMJ. 2017 Dec 13;359:j5326. doi: 10.1136/bmj.j5326. PubMed PMID: 29237605; PubMed Central PMCID: PMC5728253.

8: Todd L, Suarez L, Quinn C, Fischer AJ. Retinoic Acid-Signaling Regulates the Proliferative and Neurogenic Capacity of Müller Glia-Derived Progenitor Cells in the Avian Retina. Stem Cells. 2018 Mar;36(3):392-405. doi: 10.1002/stem.2742. Epub 2017 Nov 27. PubMed PMID: 29193451; PubMed Central PMCID: PMC5823757.

9: Judith Vijaya J, Jayaprakash N, Kombaiah K, Kaviyarasu K, John Kennedy L, Jothi Ramalingam R, Al-Lohedan HA, V M MA, Maaza M. Bioreduction potentials of dried root of Zingiber officinale for a simple green synthesis of silver nanoparticles: Antibacterial studies. J Photochem Photobiol B. 2017 Dec;177:62-68. doi: 10.1016/j.jphotobiol.2017.10.007. Epub 2017 Oct 7. PubMed PMID: 29069633.

10: Yang SW, Zhou YJ, Zhao YX, Liu YY, Tian XF, Wang ZJ, Jia DA, Han HY, Hu B, Shen H, Gao F, Wang LY, Lin J, Pan GZ, Zhang J, Guo ZF, Du J, Hu DY. The serum anion gap is associated with disease severity and all-cause mortality in coronary artery disease. J Geriatr Cardiol. 2017 Jun;14(6):392-400. doi: 10.11909/j.issn.1671-5411.2017.06.008. PubMed PMID: 29056946; PubMed Central PMCID: PMC5540871.

11: Fung CH, Vaughan CP, Markland AD, Huang AJ, Mitchell MN, Bliwise DL, Ancoli-Israel S, Redline S, Alessi CA, Stone K. Nocturia is Associated with Poor Sleep Quality Among Older Women in the Study of Osteoporotic Fractures. J Am Geriatr Soc. 2017 Nov;65(11):2502-2509. doi: 10.1111/jgs.15027. Epub 2017 Sep 15. PubMed PMID: 28914959; PubMed Central PMCID: PMC5681421.

12: Wang T, Ma B, Jin A, Li X, Zhang X, Wang W, Cai Y. Facile loading of Ag nanoparticles onto magnetic microsphere by the aid of a tannic acid-Metal polymer layer to synthesize magnetic disinfectant with high antibacterial activity. J Hazard Mater. 2018 Jan 15;342:392-400. doi: 10.1016/j.jhazmat.2017.08.047. Epub 2017 Aug 20. PubMed PMID: 28850917.

13: Sindi S, Ngandu T, Hovatta I, Kåreholt I, Antikainen R, Hänninen T, Levälahti E, Laatikainen T, Lindström J, Paajanen T, Peltonen M, Khalsa DS, Wolozin B, Strandberg T, Tuomilehto J, Soininen H, Kivipelto M, Solomon A; FINGER study group. Baseline Telomere Length and Effects of a Multidomain Lifestyle Intervention on Cognition: The FINGER Randomized Controlled Trial. J Alzheimers Dis. 2017;59(4):1459-1470. doi: 10.3233/JAD-170123. PubMed PMID: 28777749; PubMed Central PMCID: PMC5611796.

14: Shi Q, Chowdhury S, Ma R, Le KX, Hong S, Caldarone BJ, Stevens B, Lemere CA. Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice. Sci Transl Med. 2017 May 31;9(392). pii: eaaf6295. doi: 10.1126/scitranslmed.aaf6295. PubMed PMID: 28566429.

15: Dreyer RP, Dharmarajan K, Hsieh AF, Welsh J, Qin L, Krumholz HM. Sex Differences in Trajectories of Risk After Rehospitalization for Heart Failure, Acute Myocardial Infarction, or Pneumonia. Circ Cardiovasc Qual Outcomes. 2017 May;10(5). pii: e003271. doi: 10.1161/CIRCOUTCOMES.116.003271. PubMed PMID: 28506980; PubMed Central PMCID: PMC5650228.

16: Tuyet LT, Nhung BT, Dao DTA, Hanh NTH, Tuyen LD, Binh TQ, Thuc VTM. The Brain-Derived Neurotrophic Factor Val66Met Polymorphism, Delivery Method, Birth Weight, and Night Sleep Duration as Determinants of Obesity in Vietnamese Children of Primary School Age. Child Obes. 2017 Oct;13(5):392-399. doi: 10.1089/chi.2017.0007. Epub 2017 May 4. PubMed PMID: 28471701.

17: Jayaprakash N, Vijaya JJ, Kaviyarasu K, Kombaiah K, Kennedy LJ, Ramalingam RJ, Munusamy MA, Al-Lohedan HA. Green synthesis of Ag nanoparticles using Tamarind fruit extract for the antibacterial studies. J Photochem Photobiol B. 2017 Apr;169:178-185. doi: 10.1016/j.jphotobiol.2017.03.013. Epub 2017 Mar 20. PubMed PMID: 28347958.

18: Holdaas H, de Fijter JW, Cruzado JM, Massari P, Nashan B, Kanellis J, Witzke O, Gutierrez-Dalmau A, Turkmen A, Wang Z, Lopez P, Bernhardt P, Kochuparampil J, van der Giet M, Murbraech K; ELEVATE Study Group. Cardiovascular Parameters to 2 years After Kidney Transplantation Following Early Switch to Everolimus Without Calcineurin Inhibitor Therapy: An Analysis of the Randomized ELEVATE Study. Transplantation. 2017 Oct;101(10):2612-2620. doi: 10.1097/TP.0000000000001739. PubMed PMID: 28333860.

19: Keijzers G, Kelly AM, Cullen L, Klim S, Graham CA, Craig S, Kuan WS, Jones P, Holdgate A, Lawoko C, Laribi S. Heart failure in patients presenting with dyspnoea to the emergency department in the Asia Pacific region: an observational study. BMJ Open. 2017 Feb 28;7(2):e013812. doi: 10.1136/bmjopen-2016-013812. PubMed PMID: 28246137; PubMed Central PMCID: PMC5337741.

20: Panés J, Sandborn WJ, Schreiber S, Sands BE, Vermeire S, D'Haens G, Panaccione R, Higgins PDR, Colombel JF, Feagan BG, Chan G, Moscariello M, Wang W, Niezychowski W, Marren A, Healey P, Maller E. Tofacitinib for induction and maintenance therapy of Crohn's disease: results of two phase IIb randomised placebo-controlled trials. Gut. 2017 Jun;66(6):1049-1059. doi: 10.1136/gutjnl-2016-312735. Epub 2017 Feb 16. PubMed PMID: 28209624; PubMed Central PMCID: PMC5532457.