WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 596636
CAS#: 132055-38-0
Description: L 685487 is formed by microbial transformation of FR 900520.
MedKoo Cat#: 596636
Name: L 685487
CAS#: 132055-38-0
Chemical Formula: C42H67NO12
Exact Mass: 777.4663
Molecular Weight: 777.99
Elemental Analysis: C, 64.84; H, 8.68; N, 1.80; O, 24.68
This product is not in stock, which may be available by custom synthesis.
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Synonym: L 685487; L-685487; L685487; 13-Desmethyl FR 900520;
IUPAC/Chemical Name: 16,19-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,15,19-trihydroxy-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl)-14-methoxy-4,10,12,18-tetramethyl-, (3S-(3R*(E(1S*,3S*,4S*)),4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*))-
InChi Key: HODQTLITXRGFLM-SFCOAMDPSA-N
InChi Code: InChI=1S/C42H67NO12/c1-9-29-17-23(2)16-24(3)18-35(53-8)37(47)36-20-26(5)42(51,55-36)39(48)40(49)43-15-11-10-12-30(43)41(50)54-38(27(6)32(45)22-33(29)46)25(4)19-28-13-14-31(44)34(21-28)52-7/h17,19,24,26-32,34-38,44-45,47,51H,9-16,18,20-22H2,1-8H3/b23-17+,25-19+/t24-,26+,27+,28-,29+,30-,31?,32-,34?,35-,36-,37+,38+,42+/m0/s1
SMILES Code: O=C([C@@](CCCC1)([H])N1C(C([C@@]2(O)[C@H](C)C[C@@](O2)([H])[C@H](O)[C@@H](OC)C[C@@H](C)C/C(C)=C/[C@H]3CC)=O)=O)O[C@H](/C(C)=C/[C@H]4CC(OC)C(O)CC4)[C@H](C)[C@@H](O)CC3=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 777.99 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Chen TS, Arison BH, Wicker LS, Inamine ES. Microbial transformation of immunosuppressive compounds. II. Specific desmethylation of 13-methoxy group of FK 506 and FR 900520 by an unidentified Actinomycete ATCC 53828 [corrected]. J Antibiot (Tokyo). 1992 Apr;45(4):577-80. Erratum in: J Antibiot (Tokyo) 1992 Jun;45(6):C-2. PubMed PMID: 1375593.
