L 685434

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596633

CAS#: 126456-36-8

Description: L 685434 is a pseudopeptide with activity against HIV protease.

Chemical Structure

L 685434
CAS# 126456-36-8

Theoretical Analysis

MedKoo Cat#: 596633
Name: L 685434
CAS#: 126456-36-8
Chemical Formula: C33H40N2O5
Exact Mass: 544.2937
Molecular Weight: 544.69
Elemental Analysis: C, 72.77; H, 7.40; N, 5.14; O, 14.69

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: L 685434; L-685434; L685434; L-685,434; L 685,434; L685,434;

IUPAC/Chemical Name: tert-butyl ((2R,3S,5R)-5-benzyl-3-hydroxy-6-((2-hydroxy-2,3-dihydro-1H-inden-1-yl)amino)-6-oxo-1-phenylhexan-2-yl)carbamate


InChi Code: InChI=1S/C33H40N2O5/c1-33(2,3)40-32(39)34-27(19-23-14-8-5-9-15-23)28(36)21-25(18-22-12-6-4-7-13-22)31(38)35-30-26-17-11-10-16-24(26)20-29(30)37/h4-17,25,27-30,36-37H,18-21H2,1-3H3,(H,34,39)(H,35,38)/t25-,27-,28+,29?,30?/m1/s1

SMILES Code: O=C(OC(C)(C)C)N[C@H](CC1=CC=CC=C1)[C@@H](O)C[C@@H](CC2=CC=CC=C2)C(NC3C(O)CC4=C3C=CC=C4)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 544.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Smith AB 3rd, Hirschmann R, Pasternak A, Yao W, Sprengeler PA, Holloway MK, Kuo LC, Chen Z, Darke PL, Schleif WA. An orally bioavailable pyrrolinone inhibitor of HIV-1 protease: computational analysis and X-ray crystal structure of the enzyme complex. J Med Chem. 1997 Aug 1;40(16):2440-4. PubMed PMID: 9258349.

2: Young SD, Payne LS, Thompson WJ, Gaffin N, Lyle TA, Britcher SF, Graham SL, Schultz TH, Deana AA, Darke PL, et al. HIV-1 protease inhibitors based on hydroxyethylene dipeptide isosteres: an investigation into the role of the P1' side chain on structure-activity. J Med Chem. 1992 May 15;35(10):1702-9. PubMed PMID: 1588552.