WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 596631
CAS#: 95417-67-7
Description: L 687384 is a high-affinity sigma receptor ligand.
MedKoo Cat#: 596631
Name: L 687384
CAS#: 95417-67-7
Chemical Formula: C21H25N
Exact Mass: 291.1987
Molecular Weight: 291.43
Elemental Analysis: C, 86.55; H, 8.65; N, 4.81
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
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Synonym: L 687384; L-687384; L687384; L-687,384; L 687,384; L687,384;
IUPAC/Chemical Name: 1'-benzyl-3,4-dihydro-2H-spiro[naphthalene-1,4'-piperidine]
InChi Key: MLDCBJPLHBPJET-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H25N/c1-2-7-18(8-3-1)17-22-15-13-21(14-16-22)12-6-10-19-9-4-5-11-20(19)21/h1-5,7-9,11H,6,10,12-17H2
SMILES Code: C12=C(C3(CCN(CC4=CC=CC=C4)CC3)CCC2)C=CC=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 291.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Couture S, Debonnel G. Some of the effects of the selective sigma ligand (+)pentazocine are mediated via a naloxone-sensitive receptor. Synapse. 2001 Mar 15;39(4):323-31. PubMed PMID: 11169783.
2: Bergeron R, Debonnel G. Effects of low and high doses of selective sigma ligands: further evidence suggesting the existence of different subtypes of sigma receptors. Psychopharmacology (Berl). 1997 Feb;129(3):215-24. PubMed PMID: 9084059.
3: McLarnon J, Sawyer D, Church J. The actions of L-687,384, a sigma receptor ligand, on NMDA-induced currents in cultured rat hippocampal pyramidal neurons. Neurosci Lett. 1994 Jun 20;174(2):181-4. PubMed PMID: 7526288.
