PAN12314

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 562918

CAS#: 809612-31-4 (free base)

Description: PAN12314, also known as Compound 5a, is a 5-HT4R partial agonists that displayed cognition-enhancing properties in animal models. This product has no formal name at the moment. For the convenience of communication, a temporary code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).

Chemical Structure

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PAN12314
CAS# 809612-31-4 (free base)
Instruction

Theoretical Analysis

MedKoo Cat#: 562918
Name: PAN12314
CAS#: 809612-31-4 (free base)
Chemical Formula: C21H30N4O2
Exact Mass: 370.24
Molecular Weight: 370.490
Elemental Analysis: C, 68.08; H, 8.16; N, 15.12; O, 8.64

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 809612-31-4 (free base)   1809612-32-5 (TFA)    

Synonym: 5a; 5a Series 1; Compund 5a; PAN12314; PAN-12314; PAN 12314;

IUPAC/Chemical Name: 3-isopropyl-N-(((1R,5S)-3-(3-methoxypropyl)-3-azabicyclo[3.1.0]hexan-6-yl)methyl)imidazo[1,5-a]pyridine-1-carboxamide

InChi Key: PIWCAMJYLCDVQL-ALOPSCKCSA-N

InChi Code: InChI=1S/C21H30N4O2/c1-14(2)20-23-19(18-7-4-5-9-25(18)20)21(26)22-11-15-16-12-24(13-17(15)16)8-6-10-27-3/h4-5,7,9,14-17H,6,8,10-13H2,1-3H3,(H,22,26)/t15?,16-,17+

SMILES Code: CC(C)C1=NC(C(NCC2[C@@]3([H])[C@]2([H])CN(CCCOC)C3)=O)=C4N1C=CC=C4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
Soluble in DMSO 0.0 0.00

Preparing Stock Solutions

The following data is based on the product molecular weight 370.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Nirogi R, Mohammed AR, Shinde AK, Bogaraju N, Gagginapalli SR, Ravella SR, Kota L, Bhyrapuneni G, Muddana NR, Benade V, Palacharla RC, Jayarajan P, Subramanian R, Goyal VK. Synthesis and SAR of Imidazo[1,5-a]pyridine derivatives as 5-HT4 receptor partial agonists for the treatment of cognitive disorders associated with Alzheimer's disease. Eur J Med Chem. 2015 Oct 20;103:289-301. doi: 10.1016/j.ejmech.2015.08.051. Epub 2015 Sep 1. PMID: 26363507.