L 659874

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596611

CAS#: 125989-15-3

Description: L 659874 is a cyclic hexapeptide; tachykinin antagonist.

Chemical Structure

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L 659874
CAS# 125989-15-3
Instruction

Theoretical Analysis

MedKoo Cat#: 596611
Name: L 659874
CAS#: 125989-15-3
Chemical Formula: C40H55N9O8S
Exact Mass: 821.39
Molecular Weight: 821.990
Elemental Analysis: C, 58.45; H, 6.74; N, 15.34; O, 15.57; S, 3.90

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: L 659874; L-659874; L659874;

IUPAC/Chemical Name: (S)-2-((S)-2-((S)-2-acetamido-4-methylpentanamido)-4-(methylthio)butanamido)-N1-((S)-1-(((S)-1-((2-amino-2-oxoethyl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)pentanediamide

InChi Key: RDESGNZZHYRWNM-ZTTXAYQISA-N

InChi Code: 1S/C40H55N9O8S/c1-23(2)18-31(45-24(3)50)39(56)47-30(16-17-58-4)38(55)46-29(14-15-34(41)51)37(54)49-33(20-26-21-43-28-13-9-8-12-27(26)28)40(57)48-32(36(53)44-22-35(42)52)19-25-10-6-5-7-11-25/h5-13,21,23,29-33,43H,14-20,22H2,1-4H3,(H2,41,51)(H2,42,52)(H,44,53)(H,45,50)(H,46,55)(H,47,56)(H,48,57)(H,49,54)/t29-,30-,31-,32-,33-/m0/s1

SMILES Code: CC(C[C@H](NC(C)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N)=O)=O)Cc1ccccc1)=O)Cc2c3ccccc3[nH]c2)=O)CCC(N)=O)=O)CCSC)=O)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 821.99 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Munro FE, Fleetwood-Walker SM, Parker RM, Mitchell R. The effects of neurokinin receptor antagonists on mustard oil-evoked activation of rat dorsal horn neurons. Neuropeptides. 1993 Nov;25(5):299-305. PubMed PMID: 8115032.

2: Fleetwood-Walker SM, Parker RM, Munro FE, Young MR, Hope PJ, Mitchell R. Evidence for a role of tachykinin NK2 receptors in mediating brief nociceptive inputs to rat dorsal horn (laminae III-V) neurons. Eur J Pharmacol. 1993 Sep 28;242(2):173-81. PubMed PMID: 8253113.

3: Fan TP, Hu DE, Guard S, Gresham GA, Watling KJ. Stimulation of angiogenesis by substance P and interleukin-1 in the rat and its inhibition by NK1 or interleukin-1 receptor antagonists. Br J Pharmacol. 1993 Sep;110(1):43-9. PubMed PMID: 7693287; PubMed Central PMCID: PMC2176009.

4: Hall JM, Flowers JM, Morton IK. A pharmacological study of NK1 and NK2 tachykinin receptor characteristics in the rat isolated urinary bladder. Br J Pharmacol. 1992 Nov;107(3):777-84. PubMed PMID: 1282072; PubMed Central PMCID: PMC1907736.

5: Suman-Chauhan N, Guard S, Williams BJ, Watling KJ. Pharmacological characterization of tachykinin-stimulated inositol phospholipid hydrolysis in peripheral tissues. Br J Pharmacol. 1990 Dec;101(4):1001-5. PubMed PMID: 1707702; PubMed Central PMCID: PMC1917849.