L 659837

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596609

CAS#: 125989-10-8

Description: L 659837 is an ANC-2 is a lactam; tackykinin antagonist.

Chemical Structure

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L 659837
CAS# 125989-10-8
Instruction

Theoretical Analysis

MedKoo Cat#: 596609
Name: L 659837
CAS#: 125989-10-8
Chemical Formula: C40H52N8O7S
Exact Mass: 788.37
Molecular Weight: 788.960
Elemental Analysis: C, 60.89; H, 6.64; N, 14.20; O, 14.19; S, 4.06

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: L 659837; L-659837; L659837; L-659,837 L 659,837; L659,837;

IUPAC/Chemical Name: (S)-N1-((S)-3-(1H-indol-3-yl)-1-oxo-1-(((S)-1-oxo-3-phenylpropan-2-yl)amino)propan-2-yl)-2-((S,Z)-2-((S)-2-((R)-3-amino-2-oxopyrrolidin-1-yl)-4-methylpentanamido)-4-(methylthio)but-3-enamido)pentanediamide

InChi Key: UXGOMHKZXISRJP-JSEVQACXSA-N

InChi Code: 1S/C40H52N8O7S/c1-24(2)19-34(48-17-15-29(41)40(48)55)39(54)46-32(16-18-56-3)37(52)45-31(13-14-35(42)50)36(51)47-33(21-26-22-43-30-12-8-7-11-28(26)30)38(53)44-27(23-49)20-25-9-5-4-6-10-25/h4-12,16,18,22-24,27,29,31-34,43H,13-15,17,19-21,41H2,1-3H3,(H2,42,50)(H,44,53)(H,45,52)(H,46,54)(H,47,51)/b18-16-/t27-,29+,31-,32-,33-,34-/m0/s1

SMILES Code: CC(C)C[C@H](N1C([C@H](N)CC1)=O)C(N[C@@H](/C=C\SC)C(N[C@@H](CCC(N)=O)C(N[C@@H](Cc(c[nH]2)c3c2cccc3)C(N[C@@H](Cc4ccccc4)C=O)=O)=O)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 788.96 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Palea S, Corsi M, Artibani W, Ostardo E, Pietra C. Pharmacological characterization of tachykinin NK2 receptors on isolated human urinary bladder, prostatic urethra and prostate. J Pharmacol Exp Ther. 1996 May;277(2):700-5. PubMed PMID: 8627548.

2: Corsi M, Palea S, Pietra C, Oliosi B, Gaviraghi G, Sugg E, Van Amsterdam FT, Trist DG. A further analysis of the contraction induced by activation of cholecystokinin A receptors in guinea pig isolated ileum longitudinal muscle-myenteric plexus. J Pharmacol Exp Ther. 1994 Aug;270(2):734-40. PubMed PMID: 7520941.

3: Kunitomo M, Imaizumi N, Sameshima E, Fujiwara M. Pharmacological analysis of receptors involved in tachykininergic contraction induced by electrical transmural stimulation in the rabbit iris sphincter muscle. Regul Pept. 1993 Jul 2;46(1-2):282-4. PubMed PMID: 7692516.

4: McKnight AT, Maguire JJ, Elliott NJ, Fletcher AE, Foster AC, Tridgett R, Williams BJ, Longmore J, Iversen LL. Pharmacological specificity of novel, synthetic, cyclic peptides as antagonists at tachykinin receptors. Br J Pharmacol. 1991 Oct;104(2):355-60. PubMed PMID: 1665732; PubMed Central PMCID: PMC1908569.