Aftobetin | CAS#1208971-05-4 | biochemical

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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 591331

CAS#: 1208971-05-4 (free base)

Description: Aftobetin, also known as ANCA11 and NCE-11, is a novel amyloid–binding compound applied topically in the form of an ophthalmic ointment. Aftobetin may be of useful as an aid in the diagnosis Alzheimer's disease.

Chemical Structure

Aftobetin free base

CAS# 1208971-05-4 (free base)

Product data Instruction

Theoretical Analysis

MedKoo Cat#: 591331
Name: Aftobetin free base
CAS#: 1208971-05-4 (free base)
Chemical Formula: C26H32N2O5
Exact Mass: 452.23
Molecular Weight: 452.551
Elemental Analysis: C, 69.01; H, 7.13; N, 6.19; O, 17.68

Price and Availability

Size	Price	Availability
5mg	USD 250	Ready to Ship
10mg	USD 450	Ready to Ship
25mg	USD 750	Ready to Ship
50mg	USD 1250	Ready to Ship
100mg	USD 2150	Ready to Ship
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Related CAS #: 1353222-83-9 (HCl) 1208971-05-4 (free base)

Synonym: Aftobetin; ANCA11; ANCA11; ANCA11; NCE-11; NCE11; NCE 11; Compound #11, Aftobetin;

IUPAC/Chemical Name: 2-(2-(2-Methoxyethoxy)ethoxy)ethyl (2E)-2-cyano-3-(6-(piperidin-1-yl)naphthalen-2-yl)prop-2-enoate

InChi Key: NRZNTGUFHSJBTD-HKOYGPOVSA-N

InChi Code: InChI=1S/C26H32N2O5/c1-30-11-12-31-13-14-32-15-16-33-26(29)24(20-27)18-21-5-6-23-19-25(8-7-22(23)17-21)28-9-3-2-4-10-28/h5-8,17-19H,2-4,9-16H2,1H3/b24-18+

SMILES Code: O=C(OCCOCCOCCOC)/C(C#N)=C/C1=CC=C2C=C(N3CCCCC3)C=CC2=C1

Appearance: Viscous liquid

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:

Product Data

Certificate of Analysis:

View CoA: current batch, Lot#Y23X01M19

QC Data:

View QC data: current batch, Lot#Y23X01M19

Safety Data Sheet (SDS):

View Safety Data Sheet (SDS)

Instruction:

View handling instruction

Biological target:	Aftobetin, also known as ANCA11 and NCE-11, is a novel amyloid–binding compound applied topically in the form of an ophthalmic ointment.
In vitro activity:	This chapter presents protocols for the synthesis and use of ANCA-11 as an environmentally-sensitive amyloid-targeting probe that can fluorescently discriminate between amyloids with different disease origin. Reference: Methods Enzymol. 2020;639:91-114. https://pubmed.ncbi.nlm.nih.gov/32475414/
In vivo activity:	TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 452.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:	1. Teppang KL, Ehrlich RS, Yang J. Method to discriminate amyloids using fluorescent probes. Methods Enzymol. 2020;639:91-114. doi: 10.1016/bs.mie.2020.04.010. Epub 2020 Apr 25. PMID: 32475414.
In vitro protocol:	1. Teppang KL, Ehrlich RS, Yang J. Method to discriminate amyloids using fluorescent probes. Methods Enzymol. 2020;639:91-114. doi: 10.1016/bs.mie.2020.04.010. Epub 2020 Apr 25. PMID: 32475414.
In vivo protocol:	TBD

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