L 651896

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596595

CAS#: 99134-29-9

Description: L 651896 is a 5-lipoxygenase inhibitor.

Chemical Structure

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L 651896
CAS# 99134-29-9
Instruction

Theoretical Analysis

MedKoo Cat#: 596595
Name: L 651896
CAS#: 99134-29-9
Chemical Formula: C18H18O3
Exact Mass: 282.13
Molecular Weight: 282.330
Elemental Analysis: C, 76.57; H, 6.43; O, 17.00

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: L 651896; L-651896; L651896;

IUPAC/Chemical Name: (E)-6-(3-(2-(hydroxymethyl)phenyl)allyl)-2,3-dihydrobenzofuran-5-ol

InChi Key: RRKABGWFFMSVQH-ZZXKWVIFSA-N

InChi Code: InChI=1S/C18H18O3/c19-12-16-5-2-1-4-13(16)6-3-7-14-11-18-15(8-9-21-18)10-17(14)20/h1-6,10-11,19-20H,7-9,12H2/b6-3+

SMILES Code: OC1=C(C/C=C/C2=CC=CC=C2CO)C=C(OCC3)C3=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 282.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Millichamp NJ, Dziezyc J, Rohde BH, Chiou GC, Smith WB. Acute effects of anti-inflammatory drugs on neodymium:yttrium aluminum garnet laser-induced uveitis in dogs. Am J Vet Res. 1991 Aug;52(8):1279-84. PubMed PMID: 1656823.

2: Hammond ML, Zambias RA, Chang MN, Jensen NP, McDonald J, Thompson K, Boulton DA, Kopka IE, Hand KM, Opas EE, et al. Antioxidant-based inhibitors of leukotriene biosynthesis. The discovery of 6-[1-[2-(hydroxymethyl)phenyl]-1-propen-3-yl]-2,3-dihydro-5- benzofuranol, a potent topical antiinflammatory agent. J Med Chem. 1990 Mar;33(3):908-18. PubMed PMID: 2308140.

3: Dembinska-Kiec A, Novak P, Peskar BM, Peskar BA. Release of cysteinyl leukotrienes is of minor importance in platelet-activating factor-induced reduction of perfusion rate in the rat gastric vascular bed. Prog Clin Biol Res. 1989;301:487-91. PubMed PMID: 2798459.

4: Dembinska-Kiec A, Peskar BA, Muller MK, Peskar BM. The effects of platelet-activating factor on flow rate and eicosanoid release in the isolated perfused rat gastric vascular bed. Prostaglandins. 1989 Jan;37(1):69-91. PubMed PMID: 2717778.

5: Jones TR, Charette L, Denis D. Leukotriene and anti-IgE induced contractions of human isolated trachea: studies with leukotriene receptor antagonists and a novel 5-lipoxygenase inhibitor. Can J Physiol Pharmacol. 1988 Jun;66(6):762-8. PubMed PMID: 2844372.

6: Matuszewski BK, Constanzer ML, Bayne WF. Determination of 2,3-dihydro-6-[3-(2-hydroxymethyl)phenyl-2-propenyl]-5-benzofuranol in plasma using liquid chromatography with electrochemical detection. J Chromatogr. 1988 Apr 29;426(2):295-304. PubMed PMID: 3392142.

7: Bonney RJ, Davies P, Dougherty H, Egan RW, Gale PH, Chang M, Hammond M, Jensen N, MacDonald J, Thompson K, et al. Biochemical and biological activities of 2,3-dihydro-6-[3-(2-hydroxymethyl)phenyl-2-propenyl]-5-benzofuranol (L-651,896), a novel topical anti-inflammatory agent. Biochem Pharmacol. 1987 Nov 15;36(22):3885-91. PubMed PMID: 3120729.

8: Garceau D, Ford-Hutchinson AW, Charleson S. 5-Lipoxygenase inhibitors and allergic conjunctivitis reactions in the guinea-pig. Eur J Pharmacol. 1987 Nov 3;143(1):1-7. PubMed PMID: 2826183.

9: Chan CC, Dubois L, Young V. Effects of two novel inhibitors of 5-lipoxygenase, L-651,392 and L-651,896, in a guinea-pig model of epidermal hyperproliferation. Eur J Pharmacol. 1987 Jul 2;139(1):11-8. PubMed PMID: 2820754.