L-649923

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 559095

CAS#: 114370-57-9

Description: L-649923 is a bioactive chemical.


Chemical Structure

img
L-649923
CAS# 114370-57-9

Theoretical Analysis

MedKoo Cat#: 559095
Name: L-649923
CAS#: 114370-57-9
Chemical Formula: C25H31NaO6S
Exact Mass: 482.17
Molecular Weight: 482.560
Elemental Analysis: C, 62.22; H, 6.48; Na, 4.76; O, 19.89; S, 6.64

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: L-649923; L 649923; L649923;

IUPAC/Chemical Name: sodium rel-(3R,4S)-4-(4-((3-(4-acetyl-3-hydroxy-2-propylphenoxy)propyl)thio)phenyl)-4-hydroxy-3-methylbutanoate

InChi Key: HYMFDMFIXDCBBD-AUALFVNHSA-M

InChi Code: InChI=1S/C25H32O6S.Na/c1-4-6-21-22(12-11-20(17(3)26)25(21)30)31-13-5-14-32-19-9-7-18(8-10-19)24(29)16(2)15-23(27)28;/h7-12,16,24,29-30H,4-6,13-15H2,1-3H3,(H,27,28);/q;+1/p-1/t16-,24+;/m1./s1

SMILES Code: O=C([O-])C[C@@H](C)[C@H](O)C1=CC=C(SCCCOC2=CC=C(C(C)=O)C(O)=C2CCC)C=C1.[Na+]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 482.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Gyömber E, Vattay P, Szabo S, Rainsford KD. Effect of lipoxygenase inhibitors and leukotriene antagonists on acute and chronic gastric haemorrhagic mucosal lesions in ulcer models in the rat. J Gastroenterol Hepatol. 1996 Oct;11(10):922-7. PubMed PMID: 8912128.

2: Jorgensen NK, Lambert IH, Hoffmann EK. Role of LTD4 in the regulatory volume decrease response in Ehrlich ascites tumor cells. J Membr Biol. 1996 May;151(2):159-73. PubMed PMID: 8661498.

3: Cicala C, Cirino G. Phospholipase A2-induced hypotension in the rat and its pharmacological modulation. Gen Pharmacol. 1993 Sep;24(5):1197-202. PubMed PMID: 8270179.

4: Leikauf GD. Mechanisms of aldehyde-induced bronchial reactivity: role of airway epithelium. Res Rep Health Eff Inst. 1992 Feb;(49):1-35. PubMed PMID: 1315139.

5: Hu WM, Man RY. Interaction of vasoactive substances released by platelet-activating factor in the rat perfused heart. Br J Pharmacol. 1991 Dec;104(4):933-7. PubMed PMID: 1810604; PubMed Central PMCID: PMC1908832.

6: Perico N, Pasini M, Gaspari F, Abbate M, Remuzzi G. Co-participation of thromboxane A2 and leukotriene C4 and D4 in mediating cyclosporine-induced acute renal failure. Transplantation. 1991 Nov;52(5):873-8. PubMed PMID: 1835198.

7: Perico N, Cornejo RP, Benigni A, Malanchini B, Ladny JR, Remuzzi G. Endothelin induces diuresis and natriuresis in the rat by acting on proximal tubular cells through a mechanism mediated by lipoxygenase products. J Am Soc Nephrol. 1991 Jul;2(1):57-69. PubMed PMID: 1655094.

8: Hu W, Kinnaird AA, Man RY. Mechanisms of the coronary vascular effects of platelet-activating factor in the rat perfused heart. Br J Pharmacol. 1991 May;103(1):1097-102. PubMed PMID: 1652337; PubMed Central PMCID: PMC1908074.

9: Chiono M, Heller RS, Andazola JJ, Herman CA. Leukotriene C4 binds to receptors and has positive inotropic effects in bullfrog heart. J Pharmacol Exp Ther. 1991 Mar;256(3):1042-8. PubMed PMID: 2005570.

10: Cicala C, Sorrentino R, Sorrentino L, Cirino G. Effect of L-649, 923, an LTD4 antagonist, on phospholipase A2-induced hypotension. Pharmacol Res. 1990 Sep-Oct;22 Suppl 3:83. PubMed PMID: 2097660.

11: Wallace JL, McKnight GW, Keenan CM, Byles NI, MacNaughton WK. Effects of leukotrienes on susceptibility of the rat stomach to damage and investigation of the mechanism of action. Gastroenterology. 1990 May;98(5 Pt 1):1178-86. PubMed PMID: 2157619.

12: Flowers BK, Proud D, Kagey-Sobotka A, Lichtenstein LM, Naclerio RM. The effect of a leukotriene antagonist on the early response to antigen. Otolaryngol Head Neck Surg. 1990 Mar;102(3):219-24. PubMed PMID: 2108408.

13: Fraser DG, Regal JF. C5a/C5ades-Arg-induced increase in blood pressure in the guinea pig: role of thromboxane. Immunopharmacology. 1990 Jan-Feb;19(1):59-68. PubMed PMID: 1968450.

14: Cirino G, Peers SH, Wallace JL, Flower RJ. A study of phospholipase A2-induced oedema in rat paw. Eur J Pharmacol. 1989 Aug 3;166(3):505-10. PubMed PMID: 2806373.

15: Leikauf GD, Doupnik CA, Leming LM, Wey HE. Sulfidopeptide leukotrienes mediate acrolein-induced bronchial hyperresponsiveness. J Appl Physiol (1985). 1989 Apr;66(4):1838-45. PubMed PMID: 2543658.

16: Cassin S, Gause G, Davis T, ter Riet M, Baker R. Do inhibitors of lipoxygenase and cyclooxygenase block neonatal hypoxic pulmonary vasoconstriction? J Appl Physiol (1985). 1989 Apr;66(4):1779-84. PubMed PMID: 2499569.

17: Sirén AL, Eimerl J, Feuerstein G. L-649,923: an antagonist of cardiac and vascular leukotriene D4 receptors. J Cardiovasc Pharmacol. 1989 Feb;13(2):210-7. PubMed PMID: 2468948.

18: Knutson L, Nimbratt C, Flemström G. Effects of leukotriene D4, the antagonist L-649-923, and arachidonic acid on duodenal bicarbonate secretion in the rat in vivo. Scand J Gastroenterol. 1988 Dec;23(10):1225-31. PubMed PMID: 3249920.

19: Del Monte M, Subissi A. Platelet-activating factor-induced contraction of guinea-pig lung parenchymal strips: possible involvement of arachidonate metabolites. Naunyn Schmiedebergs Arch Pharmacol. 1988 Oct;338(4):417-21. PubMed PMID: 3149718.

20: Jacques CA, Spur BW, Crea AE, Lee TH. The contractile activities of lipoxin A4 and lipoxin B4 for guinea-pig airway tissues. Br J Pharmacol. 1988 Oct;95(2):562-8. PubMed PMID: 2852525; PubMed Central PMCID: PMC1854178.