WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 596585
Description: L 641953 is a thromboxane receptor antagonist.
MedKoo Cat#: 596585
Name: L 641953
Chemical Formula: C15H9FO3S
Exact Mass: 288.0256
Molecular Weight: 288.29
Elemental Analysis: C, 62.49; H, 3.15; F, 6.59; O, 16.65; S, 11.12
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: L 641953; L-641953; L641953;
IUPAC/Chemical Name: (R)-8-fluorodibenzo[b,f]thiepine-3-carboxylic acid 5-oxide
InChi Key: SAHGCTPARQWSQG-HXUWFJFHSA-N
InChi Code: InChI=1S/C15H9FO3S/c16-12-5-6-13-10(7-12)3-1-9-2-4-11(15(17)18)8-14(9)20(13)19/h1-8H,(H,17,18)/t20-/m1/s1
SMILES Code: O=C(C1=CC=C(C=CC2=CC(F)=CC=C23)C([S@@]3=O)=C1)O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 288.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Welch WJ, Wilcox CS, Dunbar KR. Modulation of renin by thromboxane: studies with thromboxane synthase inhibitor, receptor antagonists, and mimetic. Am J Physiol. 1989 Oct;257(4 Pt 2):F554-60. PubMed PMID: 2508488.
2: Hall RA, Rokach JR, Bélanger P, Bianchi L, Ethier D, Ford-Hutchinson AW, Girard Y, Hamel P, Hamel R, Lord A, et al. L-641,953 (R-8-fluoro-dibenzo[b, f]thiepin-3-carboxylic acid-5-oxide): a novel thromboxane-prostaglandin endoperoxide antagonist. Can J Physiol Pharmacol. 1987 Apr;65(4):509-14. PubMed PMID: 3607600.