L 640876

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596576

CAS#: 77527-71-0

Description: L 640876 is a semisynthetic antibiotic.


Chemical Structure

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L 640876
CAS# 77527-71-0

Theoretical Analysis

MedKoo Cat#: 596576
Name: L 640876
CAS#: 77527-71-0
Chemical Formula: C22H21N7O3S2
Exact Mass: 495.1147
Molecular Weight: 495.57
Elemental Analysis: C, 53.32; H, 4.27; N, 19.78; O, 9.69; S, 12.94

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: L 640876; L-640876; L640876; L-640,876; L 640,876; L640,876;

IUPAC/Chemical Name: (6R,7R)-7-((1-benzylpyridin-1-ium-4-yl)amino)-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

InChi Key: MZRVUZHPHNYXTK-YLJYHZDGSA-N

InChi Code: InChI=1S/C22H21N7O3S2/c1-27-22(24-25-26-27)34-13-15-12-33-20-17(19(30)29(20)18(15)21(31)32)23-16-7-9-28(10-8-16)11-14-5-3-2-4-6-14/h2-10,17,20H,11-13H2,1H3,(H,31,32)/t17-,20-/m1/s1

SMILES Code: O=C1[C@@H](NC2=CC=[N+](CC3=CC=CC=C3)C=C2)[C@@]4([H])SCC(CSC5=NN=NN5C)=C(C([O-])=O)N14

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 495.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Jacks TM, Schleim KD, Miller BM, Shungu DL, Weinberg E, Gadebusch HH. Quaternary heterocyclylamino beta-lactams. V. L-640,876 treatment of induced enterotoxigenic colibacillosis (scours) in calves and piglets. J Antibiot (Tokyo). 1983 Jan;36(1):70-5. PubMed PMID: 6381448.

2: Koupal LR, Pelak BA, Cassidy PJ, Gadebusch HH. Quaternary heterocyclylamino beta-lactams. III. The mode of action of L-640,876 and the effect of NaCl on membrane permeability and binding. J Antibiot (Tokyo). 1983 Jan;36(1):54-63. PubMed PMID: 6381447.

3: Celozzi E, Pelak BA, Stapley EO, Gadebusch HH. Quaternary heterocyclylamino beta-lactams. IV. Comparison of the in vivo antibacterial activities of L-640,876, mecillinam, cefoxitin and cefotaxime. J Antibiot (Tokyo). 1983 Jan;36(1):64-9. PubMed PMID: 6088459.

4: Koupal LR, Weissberger B, Shungu DL, Weinberg E, Gadebusch HH. Quaternary heterocyclylamino beta-lactams. II. The in vitro antibacterial properties of L-640,876, a new type of beta-lactam antibiotic. J Antibiot (Tokyo). 1983 Jan;36(1):47-53. PubMed PMID: 6088458.