L 640035

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596575

CAS#: 77167-93-2

Description: L 640035 inhibits human platelet aggregation induced by arachidonic acid, collagen & prostaglandin endoperoxide analog of U44069.


Chemical Structure

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L 640035
CAS# 77167-93-2

Theoretical Analysis

MedKoo Cat#: 596575
Name: L 640035
CAS#: 77167-93-2
Chemical Formula: C15H12O3S
Exact Mass: 272.0507
Molecular Weight: 272.31
Elemental Analysis: C, 66.16; H, 4.44; O, 17.63; S, 11.77

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: L 640035; L-640035; L640035; L-640,035; L 640,035; L640,035;

IUPAC/Chemical Name: 3-(hydroxymethyl)dibenzo[b,f]thiepine 5,5-dioxide

InChi Key: NYFDVYBQHBRTNS-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H12O3S/c16-10-11-5-6-13-8-7-12-3-1-2-4-14(12)19(17,18)15(13)9-11/h1-9,16H,10H2

SMILES Code: OCC1=CC=C(C=CC2=CC=CC=C23)C(S3(=O)=O)=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 272.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Swayne GT, Maguire J, Dolan J, Raval P, Dane G, Greener M, Owen DA. Evidence for homogeneity of thromboxane A2 receptor using structurally different antagonists. Eur J Pharmacol. 1988 Aug 2;152(3):311-9. PubMed PMID: 2975605.

2: Khirabadi BS, Foegh ML, Goldstein HA, Ramwell PW. The effect of prednisolone, thromboxane, and platelet-activating factor receptor antagonists on lymphocyte and platelet migration in experimental cardiac transplantation. Transplantation. 1987 May;43(5):626-30. PubMed PMID: 3033853.

3: Ganey PE, Roth RA. Thromboxane does not mediate pulmonary vascular response to monocrotaline pyrrole. Am J Physiol. 1987 Apr;252(4 Pt 2):H743-8. PubMed PMID: 2952022.

4: Melki TS, Foegh ML, Ramwell PW. Implication of thromboxane in frusemide diuresis in rats. Clin Sci (Lond). 1986 Dec;71(6):647-50. PubMed PMID: 3791866.

5: Foegh ML, Khirabadi BS, Ramwell PW. Platelet deposition in rat heart allografts and the effect of a thromboxane receptor antagonist. J Heart Transplant. 1986 Jul-Aug;5(4):338-9. PubMed PMID: 2957473.

6: Foegh ML, Khirabadi B, Ramwell PW. Prolongation of experimental cardiac allograft survival with thromboxane-related drugs. Transplantation. 1985 Aug;40(2):124-5. PubMed PMID: 3161224.

7: Chan CC, Ford-Hutchinson A. Potentiation of the inhibitory effect of a thromboxane A2 antagonist (L-640,035) on arterial thrombosis formation in rabbit by the angiotensin converting enzyme inhibitor enalapril. Eur J Pharmacol. 1985 Apr 16;110(3):323-8. PubMed PMID: 2988983.

8: Slobodzian DK, Hsieh JY, Bayne WF. High-performance liquid chromatographic determination of 3-hydroxymethyl-dibenzo[b,f]thiepin 5,5-dioxide and its acid metabolite in human plasma and urine. J Chromatogr. 1985 Feb 27;338(1):253-8. PubMed PMID: 4019653.

9: Foegh ML, Alijani MR, Helfrich GB, Khirabadi BS, Goldman MH, Lower RR, Ramwell PW. Thromboxane and leukotrienes in clinical and experimental transplant rejection. Adv Prostaglandin Thromboxane Leukot Res. 1985;13:209-17. PubMed PMID: 2988310.

10: Foegh ML, Alijani MR, Helfrich GB, Khirabadi BS, Ramwell PW. Prolongation of cardiac allograft survival with the PAF antagonist BN-52021 and the thromboxane receptor antagonists L640035 and L636499. Adv Prostaglandin Thromboxane Leukot Res. 1985;15:381-4. PubMed PMID: 2936126.

11: Lefer AM, Burke SE, Lepran I. Preservation of ischemic myocardial tissue with an antagonist of vasoconstrictor eicosanoids. Can J Physiol Pharmacol. 1984 Dec;62(12):1487-91. PubMed PMID: 6241500.

12: McFarlane CS, Piechuta H, Hall RA, Ford-Hutchinson AW. Effects of a contractile prostaglandin antagonist (L-640,035) upon allergen-induced bronchoconstriction in hyperreactive rats and conscious squirrel monkeys. Prostaglandins. 1984 Aug;28(2):173-82. PubMed PMID: 6505224.

13: Carrier R, Cragoe EJ, Ethier D, Ford-Hutchinson AW, Girard Y, Hall RA, Hamel P, Rokach J, Share NN, Stone CA, et al. Studies on L-640,035: a novel antagonist of contractile prostanoids in the lung. Br J Pharmacol. 1984 Jun;82(2):389-95. PubMed PMID: 6428502; PubMed Central PMCID: PMC1987036.

14: Chan CC, Nathaniel DJ, Yusko PJ, Hall RA, Ford-Hutchinson AW. Inhibition of prostanoid-mediated platelet aggregation in vivo and in vitro by 3-hydroxymethyl-dibenzo(b,f)thiepin 5,5-dioxide (L-640,035). J Pharmacol Exp Ther. 1984 Apr;229(1):276-82. PubMed PMID: 6423813.