L 644257

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596574

CAS#: 68354-99-4

Description: L 644257 is a synthetic glycolipid for the study of in vivo behavior of liposomes.

Chemical Structure

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L 644257
CAS# 68354-99-4
Instruction

Theoretical Analysis

MedKoo Cat#: 596574
Name: L 644257
CAS#: 68354-99-4
Chemical Formula: C39H69NO5S
Exact Mass: 663.49
Molecular Weight: 664.040
Elemental Analysis: C, 70.54; H, 10.47; N, 2.11; O, 12.05; S, 4.83

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: L 644257; L-644257; L644257; 6-Coham; Nmanchol;

IUPAC/Chemical Name: (2R,3S,4S,5S,6R)-2-(aminomethyl)-6-((6-(((3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)hexyl)thio)tetrahydro-2H-pyran-3,4,5-triol

InChi Key: SQGBPXZJXZCRMK-LFMDNDDKSA-N

InChi Code: InChI=1S/C39H69NO5S/c1-25(2)11-10-12-26(3)30-15-16-31-29-14-13-27-23-28(17-19-38(27,4)32(29)18-20-39(30,31)5)44-21-8-6-7-9-22-46-37-36(43)35(42)34(41)33(24-40)45-37/h13,25-26,28-37,41-43H,6-12,14-24,40H2,1-5H3/t26-,28+,29+,30-,31+,32+,33-,34-,35+,36+,37-,38+,39-/m1/s1

SMILES Code: O[C@@H]([C@H]([C@@H]([C@@H](CN)O1)O)O)[C@H]1SCCCCCCO[C@H]2CC[C@]3(C)[C@@]4([H])CC[C@]5(C)[C@@H]([C@H](C)CCCC(C)C)CC[C@@]5([H])[C@]4([H])CC=C3C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 664.04 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Ponpipom MM, Hagmann WK, O'Grady LA, Jackson JJ, Wood DD, Zweerink HJ. Glycolipids as host resistance stimulators. J Med Chem. 1990 Feb;33(2):861-7. PubMed PMID: 2299649.

2: Hagmann WK, Ponpipom MM, Jackson JJ, Wood DD, Boltz RC Jr, Zweerink HJ. Steroidal glycolipid, L-644,257, is a potent enhancer of nonspecific host resistance. Int J Immunopharmacol. 1990;12(2):241-6. PubMed PMID: 2329016.

3: Schwendener RA, Lagocki PA, Rahman YE. The effects of charge and size on the interaction of unilamellar liposomes with macrophages. Biochim Biophys Acta. 1984 Apr 25;772(1):93-101. PubMed PMID: 6712952.

4: Wu MS, Robbins JC, Bugianesi RL, Ponpipom MM, Shen TY. Modified in vivo behavior of liposomes containing synthetic glycolipids. Biochim Biophys Acta. 1981 Apr 17;674(1):19-29. PubMed PMID: 7236728.