L 364918

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MedKoo CAT#: 596531

CAS#: 122211-31-8

Description: L 364918 is an oxytocin antagonist; synthetic derivative of L 156373.

Chemical Structure

L 364918
CAS# 122211-31-8

Theoretical Analysis

MedKoo Cat#: 596531
Name: L 364918
CAS#: 122211-31-8
Chemical Formula: C40H54N8O6
Exact Mass: 742.4166
Molecular Weight: 742.92
Elemental Analysis: C, 64.67; H, 7.33; N, 15.08; O, 12.92

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: L 364918; L-364918; L364918; L 364,918; L-364,918; L364,918;

IUPAC/Chemical Name: (2S)-N-(L-alloisoleucyl)-N-((R)-1-cyclohexyl-3-oxopropan-2-yl)-1-((2R)-3-(3,3-di(pyridazine-3-carbonyl)cyclohexyl)-2-(methylamino)propanoyl)-2,3-dihydro-1H-pyrrole-2-carboxamide


InChi Code: InChI=1S/C40H54N8O6/c1-4-26(2)34(41)39(54)48(29(25-49)22-27-12-6-5-7-13-27)38(53)33-17-11-21-47(33)37(52)32(42-3)23-28-14-8-18-40(24-28,35(50)30-15-9-19-43-45-30)36(51)31-16-10-20-44-46-31/h9-11,15-16,19-21,25-29,32-34,42H,4-8,12-14,17-18,22-24,41H2,1-3H3/t26-,28?,29-,32-,33+,34+/m1/s1

SMILES Code: CC[C@H]([C@H](N)C(N(C([C@@H]1CC=CN1C([C@H](NC)CC2CCCC(C(c3nnccc3)=O)(C(c4nnccc4)=O)C2)=O)=O)[C@@H](C=O)CC5CCCCC5)=O)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 742.92 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Shimazoe T, Fukumoto T, Shuto T, Watanabe S. [Role of cholecystokinin receptor in methamphetamine-induced reverse tolerance]. Nihon Shinkei Seishin Yakurigaku Zasshi. 2002 Oct;22(5):207. Japanese. PubMed PMID: 12451697.

2: Pettibone DJ, Clineschmidt BV, Anderson PS, Freidinger RM, Lundell GF, Koupal LR, Schwartz CD, Williamson JM, Goetz MA, Hensens OD, et al. A structurally unique, potent, and selective oxytocin antagonist derived from Streptomyces silvensis. Endocrinology. 1989 Jul;125(1):217-22. PubMed PMID: 2544402.