WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 596531
Description: L 364918 is an oxytocin antagonist; synthetic derivative of L 156373.
MedKoo Cat#: 596531
Name: L 364918
Chemical Formula: C40H54N8O6
Exact Mass: 742.4166
Molecular Weight: 742.92
Elemental Analysis: C, 64.67; H, 7.33; N, 15.08; O, 12.92
This product is not in stock, which may be available by custom synthesis.
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Synonym: L 364918; L-364918; L364918; L 364,918; L-364,918; L364,918;
IUPAC/Chemical Name: (2S)-N-(L-alloisoleucyl)-N-((R)-1-cyclohexyl-3-oxopropan-2-yl)-1-((2R)-3-(3,3-di(pyridazine-3-carbonyl)cyclohexyl)-2-(methylamino)propanoyl)-2,3-dihydro-1H-pyrrole-2-carboxamide
InChi Key: RDHWFPFSGVZZKM-URWURDDHSA-N
InChi Code: InChI=1S/C40H54N8O6/c1-4-26(2)34(41)39(54)48(29(25-49)22-27-12-6-5-7-13-27)38(53)33-17-11-21-47(33)37(52)32(42-3)23-28-14-8-18-40(24-28,35(50)30-15-9-19-43-45-30)36(51)31-16-10-20-44-46-31/h9-11,15-16,19-21,25-29,32-34,42H,4-8,12-14,17-18,22-24,41H2,1-3H3/t26-,28?,29-,32-,33+,34+/m1/s1
SMILES Code: CC[C@H]([C@H](N)C(N(C([C@@H]1CC=CN1C([C@H](NC)CC2CCCC(C(c3nnccc3)=O)(C(c4nnccc4)=O)C2)=O)=O)[C@@H](C=O)CC5CCCCC5)=O)C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 742.92 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Shimazoe T, Fukumoto T, Shuto T, Watanabe S. [Role of cholecystokinin receptor in methamphetamine-induced reverse tolerance]. Nihon Shinkei Seishin Yakurigaku Zasshi. 2002 Oct;22(5):207. Japanese. PubMed PMID: 12451697.
2: Pettibone DJ, Clineschmidt BV, Anderson PS, Freidinger RM, Lundell GF, Koupal LR, Schwartz CD, Williamson JM, Goetz MA, Hensens OD, et al. A structurally unique, potent, and selective oxytocin antagonist derived from Streptomyces silvensis. Endocrinology. 1989 Jul;125(1):217-22. PubMed PMID: 2544402.