L 365209

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MedKoo CAT#: 596530

CAS#: 122211-30-7

Description: L 365209 is an oxytocin antagonist; synthetic derivative of L 156373.

Chemical Structure

L 365209
CAS# 122211-30-7

Theoretical Analysis

MedKoo Cat#: 596530
Name: L 365209
CAS#: 122211-30-7
Chemical Formula: C40H50N8O6
Exact Mass: 738.3853
Molecular Weight: 738.89
Elemental Analysis: C, 65.02; H, 6.82; N, 15.17; O, 12.99

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: L 365209; L-365209; L365209; L 365,209; L-365,209; L365,209;

IUPAC/Chemical Name: 16,24-dibenzyl-13-(sec-butyl)-25-methyl-1,7,8,13,14,16,17,18a,19,20,21,24,25,26a-tetradecahydro-2H,12H-dipyridazino[1,6-a:1',6'-d]pyrrolo[1,2-j][1,4,7,10,13,16]hexaazacyclooctadecine-6,12,15,18,23,26(6aH)-hexaone


InChi Code: InChI=1S/C40H50N8O6/c1-4-26(2)34-40(54)48-32(19-12-22-42-48)39(53)47-31(18-11-21-41-47)37(51)45(3)33(25-28-16-9-6-10-17-28)38(52)46-23-13-20-30(46)36(50)43-29(35(49)44-34)24-27-14-7-5-8-15-27/h5-10,14-17,21-22,26,29-34H,4,11-13,18-20,23-25H2,1-3H3,(H,43,50)(H,44,49)

SMILES Code: CCC(C1C(N2C(C(N3C(C(N(C)C(Cc4ccccc4)C(N5CCCC5C(NC(Cc6ccccc6)C(N1)=O)=O)=O)=O)CCC=N3)=O)CCC=N2)=O)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 738.89 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Geenen V, Martens H, Robert F, Vrindts-Gevaert Y, De Groote D, Franchimont P. Immunomodulatory properties of cyclic hexapeptide oxytocin antagonists. Thymus. 1992 Dec;20(4):217-26. PubMed PMID: 1492361.

2: Williams PD, Bock MG, Tung RD, Garsky VM, Perlow DS, Erb JM, Lundell GF, Gould NP, Whitter WL, Hoffman JB, et al. Development of a novel class of cyclic hexapeptide oxytocin antagonists based on a natural product. J Med Chem. 1992 Oct 16;35(21):3905-18. PubMed PMID: 1331448.

3: Pettibone DJ, Clineschmidt BV, Lis EV, Reiss DR, Totaro JA, Woyden CJ, Bock MG, Freidinger RM, Tung RD, Veber DF, et al. In vitro pharmacological profile of a novel structural class of oxytocin antagonists. J Pharmacol Exp Ther. 1991 Jan;256(1):304-8. PubMed PMID: 1988661.

4: Grider JR, Makhlouf GM. Distinct receptors for cholecystokinin and gastrin on muscle cells of stomach and gallbladder. Am J Physiol. 1990 Aug;259(2 Pt 1):G184-90. PubMed PMID: 2382717.

5: Pettibone DJ, Clineschmidt BV, Anderson PS, Freidinger RM, Lundell GF, Koupal LR, Schwartz CD, Williamson JM, Goetz MA, Hensens OD, et al. A structurally unique, potent, and selective oxytocin antagonist derived from Streptomyces silvensis. Endocrinology. 1989 Jul;125(1):217-22. PubMed PMID: 2544402.