NGX-267 HCl

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MedKoo CAT#: 591296

CAS#: Unknown (HCl)

Description: NGX-267 is an M1 muscarinic agonist.


Price and Availability

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Pricing updated 2020-10-29. Prices are subject to change without notice.

NGX-267 HCl is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 591296
Name: NGX-267 HCl
CAS#: Unknown (HCl)
Chemical Formula: C10H19ClN2OS
Exact Mass: 214.114
Molecular Weight: 250.78
Elemental Analysis: C, 47.89; H, 7.64; Cl, 14.14; N, 11.17; O, 6.38; S, 12.78


Related CAS #: 503431-81-0 (free base)   869377-75-3 (hydrate)    

Synonym: NGX-267; NGX 267; NGX267; NGX-267 HCl; NGX-267 hydrochloride

IUPAC/Chemical Name: (S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro[4.5]decan-3-one hydrochloride

InChi Key: BKGJDJVLUHDBNZ-QRPNPIFTSA-N

InChi Code: InChI=1S/C10H18N2OS.ClH/c1-3-8-9(13)11-10(14-8)4-6-12(2)7-5-10;/h8H,3-7H2,1-2H3,(H,11,13);1H/t8-;/m0./s1

SMILES Code: O=C1[C@H](CC)SC2(CCN(C)CC2)N1.[H]Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Caccamo A, Oddo S, Billings LM, Green KN, Martinez-Coria H, Fisher A, LaFerla FM. M1 receptors play a central role in modulating AD-like pathology in transgenic mice. Neuron. 2006 Mar 2;49(5):671-82. PubMed PMID: 16504943.

2: Fisher A, Brandeis R, Bar-Ner RH, Kliger-Spatz M, Natan N, Sonego H, Marcovitch I, Pittel Z. AF150(S) and AF267B: M1 muscarinic agonists as innovative therapies for Alzheimer's disease. J Mol Neurosci. 2002 Aug-Oct;19(1-2):145-53. PubMed PMID: 12212772.