AF-2785

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 591290

CAS#: 252025-48-2

Description: AF-2785 inhibits cystic fibrosis transmembrane conductance regulator Cl(-) channels in epididymal epithelial cells.


Chemical Structure

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AF-2785
CAS# 252025-48-2

Theoretical Analysis

MedKoo Cat#: 591290
Name: AF-2785
CAS#: 252025-48-2
Chemical Formula: C17H12Cl2N2O2
Exact Mass: 346.03
Molecular Weight: 347.200
Elemental Analysis: C, 58.81; H, 3.48; Cl, 20.42; N, 8.07; O, 9.22

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: AF-2785; AF 2785; AF2785;

IUPAC/Chemical Name: 2-Propenoic acid, 3-(1-((2,4-dichlorophenyl)methyl)-1H-indazol-3-yl)-

InChi Key: JXBHFVLHFJMKPK-BQYQJAHWSA-N

InChi Code: InChI=1S/C17H12Cl2N2O2/c18-12-6-5-11(14(19)9-12)10-21-16-4-2-1-3-13(16)15(20-21)7-8-17(22)23/h1-9H,10H2,(H,22,23)/b8-7+

SMILES Code: O=C(O)/C=C/C1=NN(CC2=CC=C(Cl)C=C2Cl)C3=C1C=CC=C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 347.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Gong XD, Linsdell P, Cheung KH, Leung GP, Wong PY. Indazole inhibition of cystic fibrosis transmembrane conductance regulator Cl(-) channels in rat epididymal epithelial cells. Biol Reprod. 2002 Dec;67(6):1888-96. PubMed PMID: 12444067.

2: Cheng CY, Mo My, Grima J, Saso L, Tita B, Mruk D, Silvestrini B. Indazole carboxylic acids in male contraception. Contraception. 2002 Apr;65(4):265-8. Review. PubMed PMID: 12020774.

3: Cheng CY, Silvestrini B, Grima J, Mo MY, Zhu LJ, Johansson E, Saso L, Leone MG, Palmery M, Mruk D. Two new male contraceptives exert their effects by depleting germ cells prematurely from the testis. Biol Reprod. 2001 Aug;65(2):449-61. PubMed PMID: 11466213.

4: Gong XD, Wong PY. Characterization of Lonidamine and AF2785 blockade of the cyclic AMP-activated chloride current in rat epididymal cells. J Membr Biol. 2000 Dec 1;178(3):225-33. PubMed PMID: 11140278.

5: Gong XD, Wong YL, Leung GP, Cheng CY, Silvestrini B, Wong PY. Lonidamine and analogue AF2785 block the cyclic adenosine 3', 5'-monophosphate-activated chloride current and chloride secretion in the rat epididymis. Biol Reprod. 2000 Sep;63(3):833-8. PubMed PMID: 10952928.