CBFβ Inhibitor
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 562893

CAS#: 493028-20-9

Description: CBFβ Inhibitor is a cell-permeable inhibitor of CBFbeta,. It acts by binding to core binding factor beta.


Chemical Structure

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CBFβ Inhibitor
CAS# 493028-20-9

Theoretical Analysis

MedKoo Cat#: 562893
Name: CBFβ Inhibitor
CAS#: 493028-20-9
Chemical Formula: C12H14N2OS
Exact Mass: 234.08
Molecular Weight: 234.310
Elemental Analysis: C, 61.51; H, 6.02; N, 11.96; O, 6.83; S, 13.68

Price and Availability

Size Price Availability Quantity
5mg USD 270 2 Weeks
10mg USD 450 2 Weeks
25mg USD 850 2 Weeks
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Synonym: CBFβ Inhibitor; CBFbeta Inhibitor;

IUPAC/Chemical Name: 5-Ethyl-4-(4-methoxyphenyl)-1,3-thiazol-2-amine

InChi Key: QHRCVGXBBIRPTE-UHFFFAOYSA-N

InChi Code: InChI=1S/C12H14N2OS/c1-3-10-11(14-12(13)16-10)8-4-6-9(15-2)7-5-8/h4-7H,3H2,1-2H3,(H2,13,14)

SMILES Code: NC1=NC(C2=CC=C(OC)C=C2)=C(CC)S1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 234.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Castilla LH, Bushweller JH. Molecular Basis and Targeted Inhibition of CBFβ-SMMHC Acute Myeloid Leukemia. Adv Exp Med Biol. 2017;962:229-244. doi: 10.1007/978-981-10-3233-2_15. Review. PubMed PMID: 28299661.

2: Berg T. Small-molecule inhibitors of protein-protein interactions. Curr Opin Drug Discov Devel. 2008 Sep;11(5):666-74. Review. PubMed PMID: 18729018.

3: Imai O, Kurokawa M, Izutsu K, Hangaishi A, Maki K, Ogawa S, Chiba S, Mitani K, Hirai H. Mutational analyses of the AML1 gene in patients with myelodysplastic syndrome. Leuk Lymphoma. 2002 Mar;43(3):617-21. Review. PubMed PMID: 12002768.

4: Speck NA, Stacy T, Wang Q, North T, Gu TL, Miller J, Binder M, Marín-Padilla M. Core-binding factor: a central player in hematopoiesis and leukemia. Cancer Res. 1999 Apr 1;59(7 Suppl):1789s-1793s. Review. PubMed PMID: 10197598.