WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596468

CAS#: 1148-11-4

Description: Carbobenzoxyproline is an inhibitor of prolidase.

Chemical Structure

CAS# 1148-11-4

Theoretical Analysis

MedKoo Cat#: 596468
Name: Carbobenzoxyproline
CAS#: 1148-11-4
Chemical Formula: C13H15NO4
Exact Mass: 249.1001
Molecular Weight: 249.26
Elemental Analysis: C, 62.64; H, 6.07; N, 5.62; O, 25.67

Price and Availability

Size Price Availability Quantity
10.0g USD 250.0 2 Weeks
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Synonym: Carbobenzoxyproline; Benzyloxycarbonylproline; EINECS 214-557-4; N-Benzyloxycarbonylproline; Carbobenzoxy-S-proline;

IUPAC/Chemical Name: ((benzyloxy)carbonyl)-L-proline


InChi Code: InChI=1S/C13H15NO4/c15-12(16)11-7-4-8-14(11)13(17)18-9-10-5-2-1-3-6-10/h1-3,5-6,11H,4,7-9H2,(H,15,16)/t11-/m0/s1


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 249.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Surazynski A, Miltyk W, Prokop I, Palka J. Prolidase-dependent regulation of TGF β (corrected) and TGF β receptor expressions in human skin fibroblasts. Eur J Pharmacol. 2010 Dec 15;649(1-3):115-9. doi: 10.1016/j.ejphar.2010.09.034. Epub 2010 Sep 21. PubMed PMID: 20868675.

2: Mittal S, Song X, Vig BS, Amidon GL. Proline prodrug of melphalan targeted to prolidase, a prodrug activating enzyme overexpressed in melanoma. Pharm Res. 2007 Jul;24(7):1290-8. Epub 2007 Mar 22. PubMed PMID: 17377743.

3: Lupi A, Rossi A, Vaghi P, Gallanti A, Cetta G, Forlino A. N-benzyloxycarbonyl-L-proline: an in vitro and in vivo inhibitor of prolidase. Biochim Biophys Acta. 2005 Jun 30;1744(2):157-63. Epub 2005 Apr 9. PubMed PMID: 15878628.

4: Dolenga M, Hechtman P. Cytotoxicity of carbobenzoxy-protected amino acids. In Vitro Cell Dev Biol. 1992 May;28A(5):300-2. PubMed PMID: 1597402.