Albizziin
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596451

CAS#: 1483-07-4

Description: Albizziin is a glutamase inhibitor, a glutaminyl-tRNA synthetase inhibitor as well as an intermediate in the synthesis of heterocycles.


Chemical Structure

img
Albizziin
CAS# 1483-07-4

Theoretical Analysis

MedKoo Cat#: 596451
Name: Albizziin
CAS#: 1483-07-4
Chemical Formula: C4H9N3O3
Exact Mass: 147.06
Molecular Weight: 147.130
Elemental Analysis: C, 32.65; H, 6.17; N, 28.56; O, 32.62

Price and Availability

Size Price Availability Quantity
250mg USD 240
Bulk inquiry

Synonym: Albizziin; L-Albizziin; L-beta-Ureidoalanine; L-Albizziine; Albizzine; NSC 132089; NSC-132089; NSC132089;

IUPAC/Chemical Name: (S)-2-amino-3-ureidopropanoic acid

InChi Key: GZYFIMLSHBLMKF-REOHCLBHSA-N

InChi Code: InChI=1S/C4H9N3O3/c5-2(3(8)9)1-7-4(6)10/h2H,1,5H2,(H,8,9)(H3,6,7,10)/t2-/m0/s1

SMILES Code: N[C@@H](CNC(N)=O)C(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 147.13 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Durá MA, Flores M, Toldrá F. Purification and characterisation of a glutaminase from Debaryomyces spp.. Int J Food Microbiol. 2002 Jun 5;76(1-2):117-26. PubMed PMID: 12038568.

2: Adcock HJ, Brophy PM, Teesdale-Spittle PH, Buckberry LD. Cysteine conjugate beta-lyase activity in three species of parasitic helminth. Int J Parasitol. 1999 Apr;29(4):543-8. PubMed PMID: 10428630.

3: Wei C, Andrulis IL. Overexpression of asparagine synthetase in albizziin-resistant murine diploid embryonic stem cells. Somat Cell Mol Genet. 1993 Jul;19(4):321-30. PubMed PMID: 8105542.

4: McCarty GW, Bremner JM. Regulation of assimilatory nitrate reductase activity in soil by microbial assimilation of ammonium. Proc Natl Acad Sci U S A. 1992 Jan 15;89(2):453-6. PubMed PMID: 11607250; PubMed Central PMCID: PMC48256.

5: Winter HC, Dekker EE. 4-methyleneglutamine amidohydrolase from peanut leaves : preparation, catalytic properties, and immunological responses of a highly purified form of the enzyme. Plant Physiol. 1991 Jan;95(1):206-12. PubMed PMID: 16667952; PubMed Central PMCID: PMC1077507.

6: Richter K, Wolf G. High-affinity glutamine uptake of the rat hippocampus during postnatal development: a quantitative autoradiographic study. Neuroscience. 1990;34(1):49-55. PubMed PMID: 2325853.

7: Andrulis IL, Argonza R, Cairney AE. Molecular and genetic characterization of human cell lines resistant to L-asparaginase and albizziin. Somat Cell Mol Genet. 1990 Jan;16(1):59-65. PubMed PMID: 1968681.

8: VandeWaa EA, Williams JF, Geary TG. Effects of intermediary metabolites and electron transport inhibitors on action of chloroquine on Brugia pahangi and Onchocerca volvulus. Biochem Pharmacol. 1989 Dec 1;38(23):4327-32. PubMed PMID: 2597203.

9: Andrulis IL, Barrett MT. DNA methylation patterns associated with asparagine synthetase expression in asparagine-overproducing and -auxotrophic cells. Mol Cell Biol. 1989 Jul;9(7):2922-7. PubMed PMID: 2571077; PubMed Central PMCID: PMC362759.

10: Cartier M, Chang MW, Stanners CP. Use of the Escherichia coli gene for asparagine synthetase as a selective marker in a shuttle vector capable of dominant transfection and amplification in animal cells. Mol Cell Biol. 1987 May;7(5):1623-8. PubMed PMID: 2885740; PubMed Central PMCID: PMC365261.

11: Chmara H, Andruszkiewicz R, Borowski E. Inactivation of glucosamine-6-phosphate synthetase from Salmonella typhimurium LT2 by fumaroyl diaminopropanoic acid derivatives, a novel group of glutamine analogs. Biochim Biophys Acta. 1986 Mar 28;870(2):357-66. PubMed PMID: 3082365.

12: Andrulis IL, Evans-Blackler S, Siminovitch L. Characterization of single step albizziin-resistant Chinese hamster ovary cell lines with elevated levels of asparagine synthetase activity. J Biol Chem. 1985 Jun 25;260(12):7523-7. PubMed PMID: 2860112.

13: Ray PN, Siminovitch L, Andrulis IL. Molecular cloning of a cDNA for Chinese hamster ovary asparagine synthetase. Gene. 1984 Oct;30(1-3):1-9. PubMed PMID: 6150880.

14: Chmara H, Zähner H, Borowski E, Milewski S. Inhibition of glucosamine-6-phosphate synthetase from bacteria by anticapsin. J Antibiot (Tokyo). 1984 Jun;37(6):652-8. PubMed PMID: 6430854.

15: Andrulis IL, Duff C, Evans-Blackler S, Worton R, Siminovitch L. Chromosomal alterations associated with overproduction of asparagine synthetase in albizziin-resistant Chinese hamster ovary cells. Mol Cell Biol. 1983 Mar;3(3):391-8. PubMed PMID: 6133214; PubMed Central PMCID: PMC368547.

16: Biltz RM, Letteri JM, Pellegrino ED, Palekar A, Pinkus LM. Glutamine metabolism in bone. Miner Electrolyte Metab. 1983;9(3):125-31. PubMed PMID: 6135980.

17: Masters DS Jr, Meister A. Inhibition of homocysteine sulfonamide of glutamate synthase purified from Saccharomyces cerevisiae. J Biol Chem. 1982 Aug 10;257(15):8711-5. PubMed PMID: 7047525.

18: Oaks A, Jones K, Misra S. A comparison of glutamate synthase obtained from maize endosperms and roots. Plant Physiol. 1979 May;63(5):793-5. PubMed PMID: 16660814; PubMed Central PMCID: PMC542921.

19: Fitsner AB. [Metabolism of L-albizziin in rat liver slices]. Vopr Med Khim. 1978 Nov-Dec;24(6):832-6. Russian. PubMed PMID: 734988.

20: Sargent DR, Skinner CG. Analogs of albizziin. J Med Chem. 1971 May;14(5):465-6. PubMed PMID: 5117700.