WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 596406
CAS#: 13957-35-2
Description: L 1935 is a powerful histamine-liberator.
MedKoo Cat#: 596406
Name: L 1935
CAS#: 13957-35-2
Chemical Formula: C17H21NO2
Exact Mass: 271.1572
Molecular Weight: 271.36
Elemental Analysis: C, 75.25; H, 7.80; N, 5.16; O, 11.79
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: L 1935; Histamine-liberator L 1935; Compound l1935; L-1935; L1935;
IUPAC/Chemical Name: 4-(3-amino-1-(4-hydroxyphenyl)butyl)-2-methylphenol
InChi Key: QQXUACLYCIWJIU-UHFFFAOYSA-N
InChi Code: InChI=1S/C17H21NO2/c1-11-9-14(5-8-17(11)20)16(10-12(2)18)13-3-6-15(19)7-4-13/h3-9,12,16,19-20H,10,18H2,1-2H3
SMILES Code: OC1=CC=C(C(C2=CC=C(O)C=C2)CC(N)C)C=C1C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 271.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Kumar GC, Bhuvana K, Venkatarathnamma PN, Sarala N. Serum creatine phosphokinase as predictor of intermediate syndrome in organophosphorus poisoning. Indian J Crit Care Med. 2015 Jul;19(7):384-7. doi: 10.4103/0972-5229.160274. PubMed PMID: 26180430; PubMed Central PMCID: PMC4502490.
2: Gill SJ, Robert CH, Coletta M, Di Cera E, Brunori M. Cooperative free energies for nested allosteric models as applied to human hemoglobin. Biophys J. 1986 Oct;50(4):747-52. PubMed PMID: 3779009; PubMed Central PMCID: PMC1329852.
3: Lecomte J. [Respective role of endogenous histamine and 5-hydroxytryptamine in vascular collapse induced in rats by L 1935]. C R Seances Soc Biol Fil. 1966;160(6):1343-6. French. PubMed PMID: 4381696.
4: RADERMECKER M. [THE INFLUENCE OF AN INHIBITOR OF HISTIDINE DECARBOXYLASE ON HISTAMINE LIBERATION PRODUCED IN MAN BY THE INTRADERMAL INJECTION OF L 1935 AND THE LOCAL ANAPHYLACTIC REACTION]. Acta Allergol. 1965;20:77-83. French. PubMed PMID: 14311532.
5: LECOMTE J, MELON J, PETIT JM. [L 1935, a powerful histamine-liberator, is shown to be without effect on human broncho-pulmonary tissues]. Rev Belg Pathol Med Exp. 1960 Oct;27:212-8. French. PubMed PMID: 13760118.
6: BRANELLEC A, BRIOT M, HALPERN BN, LIACOPOULOS P, NEVEU T. [Histamine-liberating properties of a substituted butylamine (L 1935) in dogs]. C R Seances Soc Biol Fil. 1956;150(7):1302-6. French. PubMed PMID: 13397054.
7: FELDBERG W, LECOMTE J. Release of histamine by a substituted butylamine (L 1935): comparison with compound 48/80. Br J Pharmacol Chemother. 1955 Jun;10(2):254-9. PubMed PMID: 14389669; PubMed Central PMCID: PMC1509492.
