Cathepsin Inhibitor 1

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 562868

CAS#: 225120-65-0

Description: Cathepsin Inhibitor 1 is a pan-inhibitor of Cathepsin (L, L2, S, K, B).


Chemical Structure

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Cathepsin Inhibitor 1
CAS# 225120-65-0

Theoretical Analysis

MedKoo Cat#: 562868
Name: Cathepsin Inhibitor 1
CAS#: 225120-65-0
Chemical Formula: C20H24ClN5O2
Exact Mass: 401.1619
Molecular Weight: 401.89
Elemental Analysis: C, 59.77; H, 6.02; Cl, 8.82; N, 17.43; O, 7.96

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Cathepsin Inhibitor 1; Cathepsin-Inhibitor-1; CTS-IN-1; CTS IN 1;

IUPAC/Chemical Name: (S)-3-(tert-butyl)-N-(3-(3-chlorophenyl)-1-((cyanomethyl)amino)-1-oxopropan-2-yl)-1-methyl-1H-pyrazole-5-carboxamide

InChi Key: MZRVIHRERYCHBL-HNNXBMFYSA-N

InChi Code: InChI=1S/C20H24ClN5O2/c1-20(2,3)17-12-16(26(4)25-17)19(28)24-15(18(27)23-9-8-22)11-13-6-5-7-14(21)10-13/h5-7,10,12,15H,9,11H2,1-4H3,(H,23,27)(H,24,28)/t15-/m0/s1

SMILES Code: ClC1=CC=CC(C[C@@H](C(NCC#N)=O)NC(C2=CC(C(C)(C)C)=NN2C)=O)=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 401.89 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Coers J, Ranft C, Skoda RC. A truncated isoform of c-Mpl with an essential C-terminal peptide targets the full-length receptor for degradation. J Biol Chem. 2004 Aug 27;279(35):36397-404. Epub 2004 Jun 21. PubMed PMID: 15210714.

2: Zhu DM, Uckun FM. Cathepsin inhibition induces apoptotic death in human leukemia and lymphoma cells. Leuk Lymphoma. 2000 Oct;39(3-4):343-54. PubMed PMID: 11342315.