Zineb
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MedKoo CAT#: 581245

CAS#: 12122-67-7

Description: Zineb is an agricultural fungicide of the dithiocarbamate class. It has relatively low toxicity and there is little evidence of human injury from exposure. Oxidative stress is one of the major factors leading to Zineb-induced disorders. Zineb did not change the activity of any of superoxide dismutases. The activity of catalase (CAT) was reduced only by Zineb.


Chemical Structure

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Zineb
CAS# 12122-67-7

Theoretical Analysis

MedKoo Cat#: 581245
Name: Zineb
CAS#: 12122-67-7
Chemical Formula: C4H8N2S4Zn
Exact Mass: 275.8862
Molecular Weight: 277.74
Elemental Analysis: C, 17.30; H, 2.90; N, 10.09; S, 46.17; Zn, 23.54

Price and Availability

Size Price Availability Quantity
250.0mg USD 200.0 2 Weeks
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Synonym: Zineb; NSC 49513; Micide 55; Zineb 75; Zineb-R; Zinosan; Dithane 65;

IUPAC/Chemical Name: Zinc-ethylenebis(dithiocarbamate)

InChi Key: RGALBBQJPFDFCB-UHFFFAOYSA-N

InChi Code: InChI=1S/C4H8N2S4.Zn/c7-3(8)5-1-2-6-4(9)10;/h1-2H2,(H2,5,7,8)(H2,6,9,10);

SMILES Code: C(CNC(=S)[S-])NC1=S[Zn+2][SH-]1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 277.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Grosicka-Maciąg E, Szumiło M, Czeczot H, Kurpios-Piec D, Skrzycki M, Rahden-Staroń I. Modulation of antioxidant defense system by the dithiocarbamate fungicides Maneb and Zineb in Chinese hamster V79 cells and the role of N-acetyl-L-cysteine. Food Chem Toxicol. 2013 Oct;60:130-4. doi: 10.1016/j.fct.2013.07.034. Epub 2013 Jul 18. PubMed PMID: 23871785.

2: Andrioli NB, Soloneski S, Larramendy ML, Mudry MD. Cytogenetic and microtubule array effects of the zineb-containing commercial fungicide formulation Azzurro(®) on meristematic root cells of Allium cepa L. Mutat Res. 2012 Feb 18;742(1-2):48-53. doi: 10.1016/j.mrgentox.2011.11.014. Epub 2011 Dec 6. PubMed PMID: 22155123.

3: Soloneski S, Kujawski M, Scuto A, Larramendy ML. Carbamates: A study on genotoxic, cytotoxic, and apoptotic effects induced in Chinese hamster ovary (CHO-K1) cells. Toxicol In Vitro. 2015 Aug;29(5):834-44. doi: 10.1016/j.tiv.2015.03.011. Epub 2015 Mar 24. PubMed PMID: 25820133.

4: Pal DS, Mondal DK, Datta R. Identification of metal dithiocarbamates as a novel class of antileishmanial agents. Antimicrob Agents Chemother. 2015 Apr;59(4):2144-52. doi: 10.1128/AAC.05146-14. Epub 2015 Jan 26. PubMed PMID: 25624329; PubMed Central PMCID: PMC4356755.

5: Nebbia C, Dacasto M, Valenza F, Burdino E, Ugazio G, Fink-Gremmels J. Effects of the subchronic administration of zinc ethylene-bis-dithiocarbamate (zineb) to rabbits. Vet Hum Toxicol. 1995 Apr;37(2):137-42. PubMed PMID: 7631494.

6: Soloneski S, Reigosa MA, Larramendy ML. Vitamin E prevents ethylene bis(dithiocarbamate) pesticide zineb-induced sister chromatid exchange in Chinese hamster ovary cells. Mutagenesis. 2003 Nov;18(6):505-10. PubMed PMID: 14614185.

7: González M, Soloneski S, Reigosa MA, Larramendy ML. Effect of dithiocarbamate pesticide zineb and its commercial formulation, azzurro. IV. DNA damage and repair kinetics assessed by single cell gel electrophoresis (SCGE) assay on Chinese hamster ovary (CHO) cells. Mutat Res. 2003 Jan 10;534(1-2):145-54. PubMed PMID: 12504763.

8: Soloneski S, González M, Piaggio E, Reigosa MA, Larramendy ML. Effect of dithiocarbamate pesticide zineb and its commercial formulation, azzurro. III. Genotoxic evaluation on Chinese hamster ovary (CHO) cells. Mutat Res. 2002 Feb 15;514(1-2):201-12. PubMed PMID: 11815258.

9: Sarlak N, Taherifar A, Salehi F. Synthesis of nanopesticides by encapsulating pesticide nanoparticles using functionalized carbon nanotubes and application of new nanocomposite for plant disease treatment. J Agric Food Chem. 2014 May 28;62(21):4833-8. doi: 10.1021/jf404720d. Epub 2014 May 15. PubMed PMID: 24832389.

10: Nebbia C, Ferrero E, Valenza F, Castagnaro M, Re G, Gennaro Soffietti M. Pathologic changes, tissue distribution, and extent of conversion to ethylenethiourea after subacute administration of zinc ethylene-bis-dithiocarbamate (zineb) to calves with immature rumen function. Am J Vet Res. 1991 Oct;52(10):1717-22. PubMed PMID: 1767996.

11: Malik AK, Sharma V, Sharma VK, Rao AL. Column preconcentration and spectrophotometric determination of ziram and zineb in commercial samples and foodstuffs using (1,2'-pyridylazo)-2-naphthol (PAN)-naphthalene as adsorbate. J Agric Food Chem. 2004 Dec 29;52(26):7763-7. PubMed PMID: 15612751.

12: Soloneski S, Reigosa MA, Larramendy ML. Effect of the dithiocarbamate pesticide zineb and its commercial formulation, the azzurro. V. Abnormalities induced in the spindle apparatus of transformed and non-transformed mammalian cell lines. Mutat Res. 2003 Apr 20;536(1-2):121-9. PubMed PMID: 12694752.

13: Pavlovic V, Cekic S, Kamenov B, Ciric M, Krtinic D. The Effect of Ascorbic Acid on Mancozeb-Induced Toxicity in Rat Thymocytes. Folia Biol (Praha). 2015;61(3):116-23. PubMed PMID: 26213857.

14: Aulakh JS, Fekete A, Malik AK, Mahajan RK, Schmitt-Kopplin P. Capillary electrophoretic-ultraviolet method for the separation and estimation of zineb, maneb, and ferbam in food samples. J AOAC Int. 2007 May-Jun;90(3):834-7. PubMed PMID: 17580637.

15: Rasgele PG. Abnormal sperm morphology in mouse germ cells after short-term exposures to acetamiprid, propineb, and their mixture. Arh Hig Rada Toksikol. 2014 Mar;65(1):47-56. doi: 10.2478/10004-1254-65-2014-2408. PubMed PMID: 24535295.

16: Balaji B, Rajendar B, Ramanathan M. Quercetin protected isolated human erythrocytes against mancozeb-induced oxidative stress. Toxicol Ind Health. 2014 Jul;30(6):561-9. doi: 10.1177/0748233712462465. Epub 2012 Sep 28. PubMed PMID: 23024109.

17: Soloneski S, González M, Piaggio E, Apezteguía M, Reigosa MA, Larramendy ML. Effect of the dithiocarbamate pesticide zineb and its commercial formulation azzurro. I. Genotoxic evaluation on cultured human lymphocytes exposed in vitro. Mutagenesis. 2001 Nov;16(6):487-93. PubMed PMID: 11682639.

18: Yu XB, Hao K, Ling F, Wang GX. Aquatic environmental safety assessment and inhibition mechanism of chemicals for targeting Microcystis aeruginosa. Ecotoxicology. 2014 Nov;23(9):1638-47. doi: 10.1007/s10646-014-1303-x. Epub 2014 Aug 20. PubMed PMID: 25139029.

19: Ivanova B, Spiteller M. Solid-state UV-MALDI-MS assay of transition metal dithiocarbamate fungicides. Environ Sci Pollut Res Int. 2014 Jan;21(2):1163-77. doi: 10.1007/s11356-013-1837-0. Epub 2013 Jul 24. PubMed PMID: 23881588.

20: Rasgele PG, Muranli FD, Kekeçoğlu M. Assessment of the genotoxicity of propineb in mice bone marrow cells using micronucleus assay. Tsitol Genet. 2014 Jul-Aug;48(4):39-43. PubMed PMID: 25181854.

Zineb

250.0mg / USD 200.0