Salicylic acid

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 591226

CAS#: 69-72-7

Description: Salicylic acid is a compound obtained from the bark of the white willow and wintergreen leaves. It has bacteriostatic, fungicidal, and keratolytic actions.

Chemical Structure

Salicylic acid
CAS# 69-72-7

Theoretical Analysis

MedKoo Cat#: 591226
Name: Salicylic acid
CAS#: 69-72-7
Chemical Formula: C7H6O3
Exact Mass: 138.0317
Molecular Weight: 138.12
Elemental Analysis: C, 60.87; H, 4.38; O, 34.75

Price and Availability

Size Price Availability Quantity
100.0g USD 260.0 2 Weeks
500.0g USD 470.0 2 Weeks
Bulk inquiry

Synonym: Salicylic acid; NSC 180; NSC180; NSC-180

IUPAC/Chemical Name: Benzoic acid, 2-hydroxy-


InChi Code: InChI=1S/C7H6O3/c8-6-4-2-1-3-5(6)7(9)10/h1-4,8H,(H,9,10)


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 138.12 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

1: Akkad S, Serpell CJ. Degradable Polymers and Nanoparticles Built from Salicylic Acid. Macromol Rapid Commun. 2018 May 22:e1800182. doi: 10.1002/marc.201800182. [Epub ahead of print] PubMed PMID: 29786901.

2: Balić A, Bukvić Mokos Z, Marinović B, Ledić Drvar D. Tatami Mats: A Source of Pitted Keratolysis in a Martial Arts Athlete? Acta Dermatovenerol Croat. 2018 Apr;26(1):68-70. PubMed PMID: 29782305.

3: Brunet-Possenti F, Charpentier C, Collin G, Descamps D, Descamps V. Impact of anti-IL-17 treatment on cutaneous and genital HPV infection. Br J Dermatol. 2018 May 19. doi: 10.1111/bjd.16799. [Epub ahead of print] PubMed PMID: 29777619.

4: Zenti MG, Stefanutti C, Sanga V, Altomari A, Fabris A, Dauriz M, Bonora E. Evolocumab and lipoprotein apheresis combination therapy may have synergic effects to reduce low-density lipoprotein cholesterol levels in heterozygous familial hypercholesterolemia: A case report. J Clin Apher. 2018 Apr 11. doi: 10.1002/jca.21632. [Epub ahead of print] PubMed PMID: 29638018.

5: Lima LW, Pilon-Smits EAH, Schiavon M. Mechanisms of selenium hyperaccumulation in plants: A survey of molecular, biochemical and ecological cues. Biochim Biophys Acta. 2018 Apr 4. pii: S0304-4165(18)30090-4. doi: 10.1016/j.bbagen.2018.03.028. [Epub ahead of print] Review. PubMed PMID: 29626605.

6: Jetter N, Chandan N, Wang S, Tsoukas M. Field Cancerization Therapies for Management of Actinic Keratosis: A Narrative Review. Am J Clin Dermatol. 2018 Mar 26. doi: 10.1007/s40257-018-0348-7. [Epub ahead of print] Review. PubMed PMID: 29582369.

7: Yang T, Zhu LS, Meng Y, Lv R, Zhou Z, Zhu L, Lin HH, Xi DH. Alpha-momorcharin enhances Tobacco mosaic virus resistance in tobacco(NN) by manipulating jasmonic acid-salicylic acid crosstalk. J Plant Physiol. 2018 Apr;223:116-126. doi: 10.1016/j.jplph.2017.04.011. Epub 2017 Apr 29. PubMed PMID: 29574244.

8: Hermans MAW, van der Vet SQA, van Hagen PM, van Wijk RG, van Daele PLA. Low frequency of acetyl salicylic acid hypersensitivity in mastocytosis: the results of a double-blind, placebo-controlled challenge study. Allergy. 2018 Mar 22. doi: 10.1111/all.13445. [Epub ahead of print] PubMed PMID: 29569284.

9: Lopez-Tapia F, Brotherton-Pleiss C, Yue P, Murakami H, Costa Araujo AC, Reis Dos Santos B, Ichinotsubo E, Rabkin A, Shah R, Lantz M, Chen S, Tius MA, Turkson J. Linker Variation and Structure-Activity Relationship Analyses of Carboxylic Acid-based Small Molecule STAT3 Inhibitors. ACS Med Chem Lett. 2018 Feb 16;9(3):250-255. doi: 10.1021/acsmedchemlett.7b00544. eCollection 2018 Mar 8. PubMed PMID: 29541369; PubMed Central PMCID: PMC5846032.

10: Brindha R, Muthuselvam P, Senthilkumar S, Rajaguru P. Fe(0) catalyzed photo-Fenton process to detoxify the biodegraded products of azo dye Mordant Yellow 10. Chemosphere. 2018 Jun;201:77-95. doi: 10.1016/j.chemosphere.2018.02.151. Epub 2018 Feb 26. PubMed PMID: 29518737.

11: Banerjee SR, Song X, Yang X, Minn I, Lisok A, Chen Y, Bui A, Chatterjee S, Chen J, van Zijl PCM, McMahon MT, Pomper MG. Salicylic Acid-Based Polymeric Contrast Agents for Molecular Magnetic Resonance Imaging of Prostate Cancer. Chemistry. 2018 Mar 5. doi: 10.1002/chem.201800882. [Epub ahead of print] PubMed PMID: 29508450.

12: Eskiocak AH, Bassorgun Cİ, Uzun S, Uzun S. A Case of Disseminated Hypopigmented Keratoses Improved with Oral Acitretin. Case Rep Dermatol Med. 2017;2017:1617375. doi: 10.1155/2017/1617375. Epub 2017 Dec 21. PubMed PMID: 29430309; PubMed Central PMCID: PMC5752972.

13: Shrestha A, Khan A, Mishra DR, Bhuyan K, Sahoo B, Maiti IB, Dey N. WRKY71 and TGA1a physically interact and synergistically regulate the activity of a novel promoter isolated from Petunia vein-clearing virus. Biochim Biophys Acta. 2018 Feb;1861(2):133-146. doi: 10.1016/j.bbagrm.2018.01.005. Epub 2018 Feb 3. PubMed PMID: 29413896.

14: 5-Fluorouracil 0.5% and Salicylic Acid 10.0% (Actikerall) [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2017 Apr. Available from PubMed PMID: 29381294.

15: Zaman M, Khan MV, Zakariya SM, Nusrat S, Meeran SM, Alam P, Ajmal MR, Wahiduzzaman W, Shahein YE, Abouelella AM, Khan RH. Amino group of salicylic acid exhibits enhanced inhibitory potential against insulin amyloid fibrillation with protective aptitude toward amyloid induced cytotoxicity. J Cell Biochem. 2018 May;119(5):3945-3956. doi: 10.1002/jcb.26538. Epub 2018 Jan 19. PubMed PMID: 29350433.

16: Pan P, Huang YW, Oshima K, Yearsley M, Zhang J, Yu J, Arnold M, Wang LS. Could Aspirin and Diets High in Fiber Act Synergistically to Reduce the Risk of Colon Cancer in Humans? Int J Mol Sci. 2018 Jan 6;19(1). pii: E166. doi: 10.3390/ijms19010166. Review. PubMed PMID: 29316620; PubMed Central PMCID: PMC5796115.

17: Abbas G, Murtaza B, Bibi I, Shahid M, Niazi NK, Khan MI, Amjad M, Hussain M; Natasha. Arsenic Uptake, Toxicity, Detoxification, and Speciation in Plants: Physiological, Biochemical, and Molecular Aspects. Int J Environ Res Public Health. 2018 Jan 2;15(1). pii: E59. doi: 10.3390/ijerph15010059. Review. PubMed PMID: 29301332; PubMed Central PMCID: PMC5800158.

18: Yang Y, Zhou Y, Chi Y, Fan B, Chen Z. Characterization of Soybean WRKY Gene Family and Identification of Soybean WRKY Genes that Promote Resistance to Soybean Cyst Nematode. Sci Rep. 2017 Dec 19;7(1):17804. doi: 10.1038/s41598-017-18235-8. PubMed PMID: 29259331; PubMed Central PMCID: PMC5736691.

19: Platsidaki E, Balamoti E, Kouris A, Katsarou A, Mylonakis N, Vavouli C, Kontochristopoulos G. Bevacizumab-associated Sudden Onset of Multiple Monomorphic Comedones on the Scalp Successfully Treated with 30% Salicylic Acid Peels. Acta Dermatovenerol Croat. 2017 Oct;25(3):245-247. PubMed PMID: 29252179.

20: Hamamoto T, Ohtani M, Matsumoto E, Hori T, Tsuruhara I, Yashima K, Isomoto H. [A refractory case of ulcerative colitis developed after the cessation smoking achieved clinical and endoscopic remission after resuming smoking]. Nihon Shokakibyo Gakkai Zasshi. 2017;114(12):2134-2141. doi: 10.11405/nisshoshi.114.2134. Japanese. PubMed PMID: 29213024.