NW-1772

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MedKoo CAT#: 562850

CAS#: 911290-35-2

Description: NW-1772 is a highly potent, selective, reversible, and orally active monoamine oxidase B inhibitor.


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-09-26. Prices are subject to change without notice.

NW-1772 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 562850
Name: NW-1772
CAS#: 911290-35-2
Chemical Formula: C19H20ClNO6S
Exact Mass: 425.07
Molecular Weight: 425.88
Elemental Analysis: C, 53.59; H, 4.73; Cl, 8.32; N, 3.29; O, 22.54; S, 7.53


Synonym: NW-1772; NW 1772; NW1772;

IUPAC/Chemical Name: 7-[(3-chlorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one methanesulfonate

InChi Key: ZNILTQJFNAYPDD-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H16ClNO3.CH4O3S/c1-20-10-13-8-18(21)23-17-9-15(5-6-16(13)17)22-11-12-3-2-4-14(19)7-12;1-5(2,3)4/h2-9,20H,10-11H2,1H3;1H3,(H,2,3,4)

SMILES Code: O=C1C=C(CNC)C2=C(O1)C=C(OCC3=CC=CC(Cl)=C3)C=C2.CS(=O)(O)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Pisani L, Muncipinto G, Miscioscia TF, Nicolotti O, Leonetti F, Catto M, Caccia C, Salvati P, Soto-Otero R, Mendez-Alvarez E, Passeleu C, Carotti A. Discovery of a novel class of potent coumarin monoamine oxidase B inhibitors: development and biopharmacological profiling of 7-[(3-chlorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one methanesulfonate (NW-1772) as a highly potent, selective, reversible, and orally active monoamine oxidase B inhibitor. J Med Chem. 2009 Nov 12;52(21):6685-706. doi: 10.1021/jm9010127. PubMed PMID: 19810674.