WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 584446
Description: Galangin inhibits Ca2+ entry into TRPC5 expressing cells and also induces autophagy.
MedKoo Cat#: 584446
Chemical Formula: C15H10O5
Exact Mass: 270.0528
Molecular Weight: 270.24
Elemental Analysis: C, 66.67; H, 3.73; O, 29.60
Synonym: Galangin; Norizalpinin
IUPAC/Chemical Name: 3,5,7-Trihydroxy-2-phenyl-4-benzopyrone
InChi Key: VCCRNZQBSJXYJD-UHFFFAOYSA-N
InChi Code: InChI=1S/C15H10O5/c16-9-6-10(17)12-11(7-9)20-15(14(19)13(12)18)8-4-2-1-3-5-8/h1-7,16-17,19H
SMILES Code: O=C1C(O)=C(C2=CC=CC=C2)OC3=CC(O)=CC(O)=C13
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 270.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
Naylor et al (2016) Natural and synthetic flavonoid modulation of TRPC5 channels. Br.J.Pharmacol. 173 562 PMID: 26565375
Chen et al (2017) Galangin reduces the loss of dopaminergic neurons in an LPS-evoked model of Parkinson's disease in rats. Int.J.Mol.Sci. 19 PMID: 29267220
So et al (1996) Inhibition of human breast cancer cell proliferation and delay of mammary tumorigenesis by flavonoids and citrus juices. Nutr.Cancer. 26 167 PMID: 8875554
Wen et al (2012) Galangin induces autophagy through upregulation of p53 in HepG2 cells. Pharmacology. 89 247 PMID: 22507894