WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 596394
Description: L 158338 is an angiotensin receptor antagonist.
MedKoo Cat#: 596394
Name: L 158338
Chemical Formula: C24H25N7
Exact Mass: 411.2171
Molecular Weight: 411.51
Elemental Analysis: C, 70.05; H, 6.12; N, 23.83
This product is not in stock, which may be available by custom synthesis.
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Synonym: L 158338; L-158338; L158338;
IUPAC/Chemical Name: 3-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-7-methyl-2-propyl-2,3-dihydro-1H-imidazo[4,5-b]pyridine
InChi Key: KFVPXROHNNPKMZ-UHFFFAOYSA-N
InChi Code: InChI=1S/C24H25N7/c1-3-6-21-26-22-16(2)13-14-25-24(22)31(21)15-17-9-11-18(12-10-17)19-7-4-5-8-20(19)23-27-29-30-28-23/h4-5,7-14,21,26H,3,6,15H2,1-2H3,(H,27,28,29,30)
SMILES Code: CCCC1N(CC2=CC=C(C3=CC=CC=C3C4=NN=NN4)C=C2)C5=NC=CC(C)=C5N1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 411.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Owen RA, Molon-Noblot S, Hubert MF, Siegl PK, Eydelloth RS, Keenan KP. Juxtaglomerular cell hypertrophy and hyperplasia induced in rhesus monkeys by angiotensin II receptor antagonists. Lab Invest. 1994 Oct;71(4):543-51. PubMed PMID: 7967510.
2: Werrmann JG, Cohen SM. Comparison of effects of angiotensin-converting enzyme inhibition with those of angiotensin II receptor antagonism on functional and metabolic recovery in postischemic working rat heart as studied by [31P] nuclear magnetic resonance. J Cardiovasc Pharmacol. 1994 Oct;24(4):573-86. PubMed PMID: 7528840.
3: Stearns RA, Miller RR, Arison BH, Rosegay A, Smith JL, Mantlo NB, Chiu SH. Evidence for a 1,2-hydride shift in the microsomal metabolism of the heterocycle L-158,338, a nonpeptide angiotensin II receptor antagonist. Drug Metab Dispos. 1993 Jul-Aug;21(4):670-6. PubMed PMID: 8104127.