L 11204

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596385

CAS#: 55308-64-0

Description: L 11204 is an Antifertility agent in vivo; inhibitor of prostaglandin synthesis.

Chemical Structure

L 11204
CAS# 55308-64-0

Theoretical Analysis

MedKoo Cat#: 596385
Name: L 11204
CAS#: 55308-64-0
Chemical Formula: C18H17N3O
Exact Mass: 291.1372
Molecular Weight: 291.35
Elemental Analysis: C, 74.20; H, 5.88; N, 14.42; O, 5.49

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: L 11204; L-11204; L11204; DL 204; DL 204IT; DL 204 IT;

IUPAC/Chemical Name: 2-(3-ethoxyphenyl)-5,6-dihydro-[1,2,4]triazolo[5,1-a]isoquinoline


InChi Code: InChI=1S/C18H17N3O/c1-2-22-15-8-5-7-14(12-15)17-19-18-16-9-4-3-6-13(16)10-11-21(18)20-17/h3-9,12H,2,10-11H2,1H3


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 291.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Lerner LJ. Development of novel embryotoxic compounds for interceptive fertility control in the dog. J Reprod Fertil Suppl. 1989;39:251-65. PubMed PMID: 2621727.

2: Prasad RS, Vijayan E. A new non-hormonal antifertility drug DL-204: II. Effect on testicular hyaluronidase and gamma-glutamyl transpeptidase in male rats. Contraception. 1987 Nov;36(5):567-80. PubMed PMID: 2896099.

3: Prasad RS, Vijayan E. A new non-hormonal antifertility drug DL-204: I. Effects on testes and accessory glands of reproduction in male rats. Contraception. 1987 Nov;36(5):557-66. PubMed PMID: 2452050.

4: Galliani G, Lerner LJ, Caramel C, Maraschin R, Nani S, Nava A, Nava A. Pregnancy termination in dogs with novel non-hormonal compounds. Studies of 2-(3-ethoxy-phenyl)-5,6-dihydro-s-triazole [5,1-a] isoquinoline (DL 204-IT). Arzneimittelforschung. 1982;32(2):123-7. PubMed PMID: 7199914.

5: Galliani G, Cristina T, Guzzi U, Omodei-Salé A, Assandri A. Increased oral activity of a new class of non-hormonal pregnancy terminating agents. J Pharmacobiodyn. 1982 Jan;5(1):55-61. PubMed PMID: 7077522.

6: Lerner LJ, Oldani C, Vitale A. Inhibition of superovulation and alteration of ova transportation in hamsters by prostaglandin and DL-204-IT, an anti-fertility agent. Prostaglandins Med. 1981 Apr;6(4):369-74. PubMed PMID: 7280116.

7: Assandri A, Perazzi A, Martinelli E, Ferrari P, Ripamonti A, Tuan G, Galliani G. Influence of metabolism on the activity of a new anti-fertility agent, 2-(3-ethoxyphenyl)-5,6-dihydro-s-triazolo [5,1-a]isoquinoline (DL 204-IT), in the rat and the hamster. Arzneimittelforschung. 1981;31(12):2104-11. PubMed PMID: 7199307.

8: Galliani G, Gallico L, Cattaneo C, Assandri A. Pregnancy terminating activity of a new non-hormonal anti-fertility agent, 2-(3-ethoxy-phenyl)-5,6-dihydro-s-triazole [5,1-a] isoquinoline (DL 204-IT) in the rat and the hamster. Studies on the factors affecting its activity. Arzneimittelforschung. 1980;30(6):972-7. PubMed PMID: 7191276.

9: Lerner LJ, Oldani C, Vitale A. Effects of prostaglandin E2 and DL204 IT, an inhibitor of prostaglandin degradation, on ovulation and ovum transport in the hamster. Prostaglandins. 1978 Mar;15(3):525-31. PubMed PMID: 566453.