NIT

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MedKoo CAT#: 562833

CAS#: 299922-10-4

Description: NIT is an inhibitor of HIV-1 protease (HIV-1p).


Price and Availability

Size Price Shipping out time Quantity
Inquire bulk and customized quantity

Pricing updated 2020-11-23. Prices are subject to change without notice.

NIT is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 562833
Name: NIT
CAS#: 299922-10-4
Chemical Formula: C15H7N3O4S2
Exact Mass: 356.9878
Molecular Weight: 357.35
Elemental Analysis: C, 50.42; H, 1.97; N, 11.76; O, 17.91; S, 17.94


Synonym: NIT;

IUPAC/Chemical Name: 4-Nitro-2-(2-thioxo-2,3-dihydro-benzothiazol-6-yl)-isoindole-1,3-dione

InChi Key: XZCFYWWZCCVGFB-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H7N3O4S2/c19-13-8-2-1-3-10(18(21)22)12(8)14(20)17(13)7-4-5-9-11(6-7)24-15(23)16-9/h1-6H,(H,16,23)

SMILES Code: O=C1N(C2=CC=C3NC(SC3=C2)=S)C(C4=C1C=CC=C4[N+]([O-])=O)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Siddiqui N, Asawa S, Birru B, Baadhe R, Rao S. PCL-Based Composite Scaffold Matrices for Tissue Engineering Applications. Mol Biotechnol. 2018 May 14. doi: 10.1007/s12033-018-0084-5. [Epub ahead of print] Review. PubMed PMID: 29761314.

2: Diwan B, Parkhey P, Gupta P. From agro-industrial wastes to single cell oils: a step towards prospective biorefinery. Folia Microbiol (Praha). 2018 Apr 23. doi: 10.1007/s12223-018-0602-7. [Epub ahead of print] Review. PubMed PMID: 29687420.

3: Yang L, Wen KS, Ruan X, Zhao YX, Wei F, Wang Q. Response of Plant Secondary Metabolites to Environmental Factors. Molecules. 2018 Mar 27;23(4). pii: E762. doi: 10.3390/molecules23040762. Review. PubMed PMID: 29584636.

4: Mohan A. Syngnathia-Congenital Maxillomandibular fusion: Case Report and Literature Review. J Oral Maxillofac Surg. 2018 May;76(5):1096.e1-1096.e6. doi: 10.1016/j.joms.2018.01.017. Epub 2018 Feb 2. Review. PubMed PMID: 29447830.

5: Berg RC, Winsvold A, Kornør H, Øverland S, Smedslund G, Hammerstrøm KT, Storetvedt K, Johnsen J, Hansen H, Tømmervik K. Effects of Opioid Agonist Treatment for Pregnant Opioid Dependent Women [Internet]. Oslo, Norway: Knowledge Centre for the Health Services at The Norwegian Institute of Public Health (NIPH); 2008 Nov. Available from http://www.ncbi.nlm.nih.gov/books/NBK464917/ PubMed PMID: 29320133.

6: Kaur Manjal S, Kaur R, Bhatia R, Kumar K, Singh V, Shankar R, Kaur R, Rawal RK. Synthetic and medicinal perspective of thiazolidinones: A review. Bioorg Chem. 2017 Dec;75:406-423. doi: 10.1016/j.bioorg.2017.10.014. Epub 2017 Oct 23. Review. PubMed PMID: 29102723.

7: Vimal A, Kumar A. Biotechnological production and practical application of L-asparaginase enzyme. Biotechnol Genet Eng Rev. 2017 Apr;33(1):40-61. doi: 10.1080/02648725.2017.1357294. Epub 2017 Aug 2. Review. PubMed PMID: 28766374.

8: Ebinger SM, Hardt J, Warschkow R, Schmied BM, Herold A, Post S, Marti L. Operative and medical treatment of chronic anal fissures-a review and network meta-analysis of randomized controlled trials. J Gastroenterol. 2017 Jun;52(6):663-676. doi: 10.1007/s00535-017-1335-0. Epub 2017 Apr 10. Review. PubMed PMID: 28396998.

9: Dheer D, Singh V, Shankar R. Medicinal attributes of 1,2,3-triazoles: Current developments. Bioorg Chem. 2017 Apr;71:30-54. doi: 10.1016/j.bioorg.2017.01.010. Epub 2017 Jan 18. Review. PubMed PMID: 28126288.

10: Zhang S, Wang Z. Effect of recombinant human brain natriuretic peptide (rhBNP) versus nitroglycerin in patients with heart failure: A systematic review and meta-analysis. Medicine (Baltimore). 2016 Nov;95(44):e4757. Review. PubMed PMID: 27858837; PubMed Central PMCID: PMC5591085.

11: Patel AK, Suri HS, Singh J, Kumar D, Shafique S, Nicolaides A, Jain SK, Saba L, Gupta A, Laird JR, Giannopoulos A, Suri JS. A Review on Atherosclerotic Biology, Wall Stiffness, Physics of Elasticity, and Its Ultrasound-Based Measurement. Curr Atheroscler Rep. 2016 Dec;18(12):83. Review. PubMed PMID: 27830569.

12: Londhe ND, Suri JS. Superharmonic Imaging for Medical Ultrasound: a Review. J Med Syst. 2016 Dec;40(12):279. Epub 2016 Oct 27. Review. PubMed PMID: 27787782.

13: Kumar A, Nayak BP, Kumar A. Obesity: single house for many evils. Minerva Endocrinol. 2016 Dec;41(4):499-508. Review. PubMed PMID: 27600644.

14: Koch E, Clark JM, Cohen B, Meinking TL, Ryan WG, Stevenson A, Yetman R, Yoon KS. Management of Head Louse Infestations in the United States-A Literature Review. Pediatr Dermatol. 2016 Sep;33(5):466-72. doi: 10.1111/pde.12982. Review. PubMed PMID: 27595869.

15: Amanzio M, Palermo S, Skyt I, Vase L. Lessons Learned From Nocebo Effects in Clinical Trials for Pain Conditions and Neurodegenerative Disorders. J Clin Psychopharmacol. 2016 Oct;36(5):475-82. doi: 10.1097/JCP.0000000000000556. Review. PubMed PMID: 27580494.

16: Panigrahy SK, Bhatt R, Kumar A. Reactive oxygen species: sources, consequences and targeted therapy in type 2 diabetes. J Drug Target. 2017 Feb;25(2):93-101. doi: 10.1080/1061186X.2016.1207650. Epub 2016 Jul 19. Review. PubMed PMID: 27356044.

17: Pia L, Garbarini F, Fossataro C, Burin D, Berti A. Sensing the body, representing the body: Evidence from a neurologically based delusion of body ownership. Cogn Neuropsychol. 2016 Feb-Mar;33(1-2):112-9. doi: 10.1080/02643294.2016.1185404. Epub 2016 Jun 17. Review. PubMed PMID: 27314302.

18: Mehrotra P. Biosensors and their applications - A review. J Oral Biol Craniofac Res. 2016 May-Aug;6(2):153-9. doi: 10.1016/j.jobcr.2015.12.002. Epub 2016 Jan 6. Review. PubMed PMID: 27195214; PubMed Central PMCID: PMC4862100.

19: Iannaccone M, D'Ascenzo F, Templin C, Omedè P, Montefusco A, Guagliumi G, Serruys PW, Di Mario C, Kochman J, Quadri G, Biondi-Zoccai G, Lüscher TF, Moretti C, D'amico M, Gaita F, Stone GW. Optical coherence tomography evaluation of intermediate-term healing of different stent types: systemic review and meta-analysis. Eur Heart J Cardiovasc Imaging. 2017 Feb;18(2):159-166. doi: 10.1093/ehjci/jew070. Epub 2016 Apr 20. Review. PubMed PMID: 27099274.

20: de Winter F, Kwok JC, Fawcett JW, Vo TT, Carulli D, Verhaagen J. The Chemorepulsive Protein Semaphorin 3A and Perineuronal Net-Mediated Plasticity. Neural Plast. 2016;2016:3679545. doi: 10.1155/2016/3679545. Epub 2016 Jan 14. Review. PubMed PMID: 27057361; PubMed Central PMCID: PMC4738953.