Pyriproxyfen
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596349

CAS#: 95737-68-1

Description: Pyriproxyfen is an insect growth regulator; a juvenile hormone analog and insect growth regulator used to control insects by disrupting metamorphosis. Has been effective in controlling mosquito larvae.


Chemical Structure

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Pyriproxyfen
CAS# 95737-68-1

Theoretical Analysis

MedKoo Cat#: 596349
Name: Pyriproxyfen
CAS#: 95737-68-1
Chemical Formula: C20H19NO3
Exact Mass: 321.1365
Molecular Weight: 321.37
Elemental Analysis: C, 74.75; H, 5.96; N, 4.36; O, 14.93

Price and Availability

Size Price Availability Quantity
50.0mg USD 330.0 2 Weeks
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Synonym: Pyriproxyfen; Sumilarv; Tiger 10EC; Knack; Pluto MC; OMS 3019; SK 591; Nylar;

IUPAC/Chemical Name: 2-((1-(4-phenoxyphenoxy)propan-2-yl)oxy)pyridine

InChi Key: NHDHVHZZCFYRSB-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H19NO3/c1-16(23-20-9-5-6-14-21-20)15-22-17-10-12-19(13-11-17)24-18-7-3-2-4-8-18/h2-14,16H,15H2,1H3

SMILES Code: CC(OC1=NC=CC=C1)COC2=CC=C(OC3=CC=CC=C3)C=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 321.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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7: Tanaka Y, Nakamura K, Oda S, Watanabe H, Tatarazako N. Estimation of population-level effect of the endocrine disruptor pyriproxyfen in Daphnia magna by using changes in sex ratio and reproductive output. Ecotoxicol Environ Saf. 2018 Jul 30;156:463-475. doi: 10.1016/j.ecoenv.2018.03.044. PubMed PMID: 29605666.

8: Rashidi F, Nouri-Ganbalani G, Imani S. Sublethal Effects of Some Insecticides on Functional Response of Habrobracon hebetor (Hymneoptera: Braconidae) When Reared on Two Lepidopteran Hosts. J Econ Entomol. 2018 Mar 20. doi: 10.1093/jee/toy069. [Epub ahead of print] PubMed PMID: 29579285.

9: Arthur FH, Ghimire MN, Myers SW, Phillips TW. Evaluation of Pyrethroid Insecticides and Insect Growth Regulators Applied to Different Surfaces for Control of Trogoderma granarium (Coleoptera: Dermestidae) the Khapra Beetle. J Econ Entomol. 2018 Apr 2;111(2):612-619. doi: 10.1093/jee/toy040. PubMed PMID: 29514245.

10: Gouveia D, Bonneton F, Almunia C, Armengaud J, Quéau H, Degli-Esposti D, Geffard O, Chaumot A. Identification, expression, and endocrine-disruption of three ecdysone-responsive genes in the sentinel species Gammarus fossarum. Sci Rep. 2018 Feb 28;8(1):3793. doi: 10.1038/s41598-018-22235-7. PubMed PMID: 29491422; PubMed Central PMCID: PMC5830573.

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13: Maharajan K, Muthulakshmi S, Nataraj B, Ramesh M, Kadirvelu K. Toxicity assessment of pyriproxyfen in vertebrate model zebrafish embryos (Danio rerio): A multi biomarker study. Aquat Toxicol. 2018 Mar;196:132-145. doi: 10.1016/j.aquatox.2018.01.010. Epub 2018 Jan 12. PubMed PMID: 29407799.

14: Parens R, Nijhout HF, Morales A, Xavier Costa F, Bar-Yam Y. A Possible Link Between Pyriproxyfen and Microcephaly. PLoS Curr. 2017 Nov 27;9. pii: ecurrents.outbreaks.5afb0bfb8cf31d9a4baba7b19b4edbac. doi: 10.1371/currents.outbreaks.5afb0bfb8cf31d9a4baba7b19b4edbac. PubMed PMID: 29362686; PubMed Central PMCID: PMC5760164.

15: Fisher A 2nd, Colman C, Hoffmann C, Fritz B, Rangel J. The Effects of the Insect Growth Regulators Methoxyfenozide and Pyriproxyfen and the Acaricide Bifenazate on Honey Bee (Hymenoptera: Apidae) Forager Survival. J Econ Entomol. 2018 Apr 2;111(2):510-516. doi: 10.1093/jee/tox347. PubMed PMID: 29361013.

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18: Watanabe H, Oda S, Abe R, Tanaka Y, Tatarazako N. Comparison of the effects of constant and pulsed exposure with equivalent time-weighted average concentrations of the juvenile hormone analog pyriproxyfen on the reproduction of Daphnia magna. Chemosphere. 2018 Mar;195:810-816. doi: 10.1016/j.chemosphere.2017.12.124. Epub 2017 Dec 22. PubMed PMID: 29289908.

19: Su T, Thieme J, Ocegueda C, Ball M, Cheng ML. Resistance to Lysinibacillus sphaericus and Other Commonly Used Pesticides in Culex pipiens (Diptera: Culicidae) from Chico, California. J Med Entomol. 2018 Feb 28;55(2):423-428. doi: 10.1093/jme/tjx235. PubMed PMID: 29272497.

20: Unlu I, Williams GM, Rochlin I, Suman D, Wang Y, Chandel K, Gaugler R. Evaluation of Lambda-Cyhalothrin and Pyriproxyfen Barrier Treatments for Aedes albopictus (Diptera: Culicidae) Management in Urbanized Areas of New Jersey. J Med Entomol. 2018 Feb 28;55(2):472-476. doi: 10.1093/jme/tjx216. PubMed PMID: 29244157.