Iproniazid
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MedKoo CAT#: 584442

CAS#: 54-92-2

Description: Iproniazid is a non-selective, irreversible monoamine oxidase (MAO) inhibitor (MAOI) that is used as an antidepressive agent.


Chemical Structure

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Iproniazid
CAS# 54-92-2

Theoretical Analysis

MedKoo Cat#: 584442
Name: Iproniazid
CAS#: 54-92-2
Chemical Formula: C9H13N3O
Exact Mass: 179.11
Molecular Weight: 179.223
Elemental Analysis: C, 60.32; H, 7.31; N, 23.45; O, 8.93

Price and Availability

Size Price Availability Quantity
100mg USD 330
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Synonym: Iproniazid; Marsilid; Iprazid

IUPAC/Chemical Name: 4-Pyridinecarboxylic acid, 2-(1-methylethyl)hydrazide

InChi Key: NYMGNSNKLVNMIA-UHFFFAOYSA-N

InChi Code: InChI=1S/C9H13N3O/c1-7(2)11-12-9(13)8-3-5-10-6-4-8/h3-7,11H,1-2H3,(H,12,13)

SMILES Code: O=C(C1=CC=NC=C1)NNC(C)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Biological target: Iproniazid is a non-selective, irreversible monoamine oxidase (MAO) inhibitor of the hydrazine class. Iproniazid has antidepressive activity.
In vitro activity: TBD
In vivo activity: The irreversible inhibition of monoamine oxidase (MAO) inside and outside monoaminergic neurones in the rat brain by the suicide inhibitors clorgyline, selegiline (l-deprenyl), pheniprazine, phenelzine, iproniazid, pargyline and the d- and l-enantiomers of tranylcypromine was determined. Reference: Biochem Pharmacol. https://pubmed.ncbi.nlm.nih.gov/2870717/

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 67.5 376.63
Ethanol 35.0 195.29
Water 67.5 376.63

Preparing Stock Solutions

The following data is based on the product molecular weight 179.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Fagervall I, Ross SB. Inhibition of monoamine oxidase in monoaminergic neurones in the rat brain by irreversible inhibitors. Biochem Pharmacol. 1986 Apr 15;35(8):1381-7. doi: 10.1016/0006-2952(86)90285-6. PMID: 2870717.
In vitro protocol: TBD
In vivo protocol: 1. Fagervall I, Ross SB. Inhibition of monoamine oxidase in monoaminergic neurones in the rat brain by irreversible inhibitors. Biochem Pharmacol. 1986 Apr 15;35(8):1381-7. doi: 10.1016/0006-2952(86)90285-6. PMID: 2870717.

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[1] Shen W, et al. Molecules. 2014, 19(11):18620-31.