WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 562823

CAS#: 1060478-12-7

Description: H2-005 is a class of selective diacylglycerol acyltransferase 2 (DGAT2) inhibitor.

Chemical Structure

CAS# 1060478-12-7

Theoretical Analysis

MedKoo Cat#: 562823
Name: H2-005
CAS#: 1060478-12-7
Chemical Formula: C24H32N4O4
Exact Mass: 440.24
Molecular Weight: 440.540
Elemental Analysis: C, 65.43; H, 7.32; N, 12.72; O, 14.53

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Synonym: H2-005; H2 005; H2005;

IUPAC/Chemical Name: 5-[(1-Ethylpropyl)amino]-3-[(2-furanylcarbonyl)amino]-1-(3-methylbutyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid methyl ester


InChi Code: InChI=1S/C24H32N4O4/c1-6-16(7-2)26-17-13-18-20(27-23(29)19-9-8-12-32-19)21(24(30)31-5)28(11-10-15(3)4)22(18)25-14-17/h8-9,12-16,26H,6-7,10-11H2,1-5H3,(H,27,29)


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Product Data:

Preparing Stock Solutions

The following data is based on the product molecular weight 440.540000000000000000000000000000 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Shortell SM, Addicott R, Walsh N, Ham C. The NHS five year forward view: lessons from the United States in developing new care models. BMJ. 2015 Apr 21;350:h2005. doi: 10.1136/bmj.h2005. PubMed PMID: 25899794. 2: Martinez-Lemus LA, Zhao G, Galiñanes EL, Boone M. Inward remodeling of resistance arteries requires reactive oxygen species-dependent activation of matrix metalloproteinases. Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2005-15. doi: 10.1152/ajpheart.01066.2010. Epub 2011 Apr 1. PubMed PMID: 21460197; PubMed Central PMCID: PMC3119084. 3: Wang Y, Chen AF, Wang DH. ET(A) receptor blockade prevents renal dysfunction in salt-sensitive hypertension induced by sensory denervation. Am J Physiol Heart Circ Physiol. 2005 Nov;289(5):H2005-11. Epub 2005 Jul 1. PubMed PMID: 15994858. 4: Song Y, Belardinelli L. ATP promotes development of afterdepolarizations and triggered activity in cardiac myocytes. Am J Physiol. 1994 Nov;267(5 Pt 2):H2005-11. PubMed PMID: 7526716.