VX-11e
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MedKoo CAT#: 562789

CAS#: 896720-20-0

Description: VX-11e is a potent and selective extracellular signal-related kinase 2 (ERK2) inhibitor.


Chemical Structure

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VX-11e
CAS# 896720-20-0

Theoretical Analysis

MedKoo Cat#: 562789
Name: VX-11e
CAS#: 896720-20-0
Chemical Formula: C24H20Cl2FN5O2
Exact Mass: 499.0978
Molecular Weight: 500.35
Elemental Analysis: C, 57.61; H, 4.03; Cl, 14.17; F, 3.80; N, 14.00; O, 6.40

Price and Availability

Size Price Availability Quantity
100.0mg USD 950.0 2 Weeks
200.0mg USD 1650.0 2 Weeks
500.0mg USD 3650.0 2 Weeks
1.0g USD 5450.0 2 Weeks
2.0g USD 9450.0 2 Weeks
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Synonym: VX-11e; VX 11e; VX11e; VTX-11e; VTX11e; VTX 11e; ERK-11e; ERK 11e; ERK11e;

IUPAC/Chemical Name: 4-[2-(2-Chloro-4-fluoroanilino)-5-methylpyrimidin-4-yl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide

InChi Key: WUTVMXLIGHTZJC-OAQYLSRUSA-N

InChi Code: InChI=1S/C24H20Cl2FN5O2/c1-13-10-29-24(31-19-6-5-17(27)9-18(19)26)32-22(13)15-8-20(28-11-15)23(34)30-21(12-33)14-3-2-4-16(25)7-14/h2-11,21,28,33H,12H2,1H3,(H,30,34)(H,29,31,32)/t21-/m1/s1

SMILES Code: O=C(C1=CC(C2=NC(NC3=CC=C(F)C=C3Cl)=NC=C2C)=CN1)N[C@@H](C4=CC=CC(Cl)=C4)CO

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 500.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Shin M, Franks CE, Hsu KL. Isoform-selective activity-based profiling of ERK signaling. Chem Sci. 2018 Feb 6;9(9):2419-2431. doi: 10.1039/c8sc00043c. eCollection 2018 Mar 7. PubMed PMID: 29732117; PubMed Central PMCID: PMC5909473.

2: Guo QS, Song Y, Hua KQ, Gao SJ. Involvement of FAK-ERK2 signaling pathway in CKAP2-induced proliferation and motility in cervical carcinoma cell lines. Sci Rep. 2017 May 18;7(1):2117. doi: 10.1038/s41598-017-01832-y. PubMed PMID: 28522860; PubMed Central PMCID: PMC5437009.

3: Krepler C, Xiao M, Sproesser K, Brafford PA, Shannan B, Beqiri M, Liu Q, Xu W, Garman B, Nathanson KL, Xu X, Karakousis GC, Mills GB, Lu Y, Ahmed TA, Poulikakos PI, Caponigro G, Boehm M, Peters M, Schuchter LM, Weeraratna AT, Herlyn M. Personalized Preclinical Trials in BRAF Inhibitor-Resistant Patient-Derived Xenograft Models Identify Second-Line Combination Therapies. Clin Cancer Res. 2016 Apr 1;22(7):1592-602. doi: 10.1158/1078-0432.CCR-15-1762. Epub 2015 Dec 16. PubMed PMID: 26673799; PubMed Central PMCID: PMC4818716.

VX-11e

100.0mg / USD 950.0