WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 591138
Description: 2-Fluoro-ADP, also known as 2-flATP, is a Fluorinated ATP Analog. This analog is designed for 19F nuclear magnetic resonance (NMR) studies of large enzymes and proteins which bind adenine nucleotides. 2-flATP is shown to be active as an ATP analog in a number of enzyme systems, and its 19F-NMR properties are determined.
MedKoo Cat#: 591138
Name: 2-Fluoro-ADP HCl
Chemical Formula: C10H14FN5O10P2
Exact Mass: 445.02
Molecular Weight: 445.19
Elemental Analysis: C, 26.98; H, 3.17; F, 4.27; N, 15.73; O, 35.94; P, 13.91
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: 2-Fluoro-ADP; ADP-beta-F; 2-flATP;
IUPAC/Chemical Name: ((2R,3S,4R,5R)-5-(6-amino-2-fluoro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl trihydrogen diphosphate hydrochloride
InChi Key: ((2R,3S,4R,5R)-5-(6-amino-2-fluoro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl trihydrogen diphosphate hydrochloride
InChi Code: InChI=1S/C10H14FN5O10P2.ClH/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(18)5(17)3(25-9)1-24-28(22,23)26-27(19,20)21;/h2-3,5-6,9,17-18H,1H2,(H,22,23)(H2,12,14,15)(H2,19,20,21);1H/t3-,5-,6-,9-;/m1./s1
SMILES Code: O[C@@H]([C@H]([C@H](N1C=NC2=C(N=C(F)N=C21)N)O3)O)[C@H]3COP(O)(OP(O)(O)=O)=O.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 445.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Sinha KK, Gross JD, Narlikar GJ. Distortion of histone octamer core promotes nucleosome mobilization by a chromatin remodeler. Science. 2017 Jan 20;355(6322). pii: eaaa3761. doi: 10.1126/science.aaa3761. PubMed PMID: 28104838; PubMed Central PMCID: PMC5656449.
2: Carter AR, Seaberg MH, Fan HF, Sun G, Wilds CJ, Li HW, Perkins TT. Sequence-dependent nanometer-scale conformational dynamics of individual RecBCD-DNA complexes. Nucleic Acids Res. 2016 Jul 8;44(12):5849-60. doi: 10.1093/nar/gkw445. Epub 2016 May 24. PubMed PMID: 27220465; PubMed Central PMCID: PMC4937329.
3: Zhang B, Muller-Steffner H, Schuber F, Potter BV. Nicotinamide 2-fluoroadenine dinucleotide unmasks the NAD+ glycohydrolase activity of Aplysia californica adenosine 5'-diphosphate ribosyl cyclase. Biochemistry. 2007 Apr 3;46(13):4100-9. Epub 2007 Mar 7. PubMed PMID: 17341094.
4: London RE, Gabel SA. Mg2+ and other polyvalent cations catalyze nucleotide fluorolysis. Arch Biochem Biophys. 1996 Oct 15;334(2):332-40. PubMed PMID: 8900408.
5: Decking UK, Alves C, Spahr R, Schrader J. 2-Fluoroadenosine uptake by erythrocytes and endothelial cells studied by 19F-NMR. Am J Physiol. 1994 Apr;266(4 Pt 2):H1596-603. PubMed PMID: 8184939.
6: Wood BE, O'Connor SE, Leff P. Adenosine 5'-(2-fluorodiphosphate) is not a selective P2Y purinoceptor agonist in the rabbit jugular vein. J Pharmacol Exp Ther. 1992 Aug;262(2):566-9. PubMed PMID: 1501113.
7: Wood BE, Squire A, O'Connor SE, Leff P. ADP-beta-F is not a selective P2y-receptor agonist in rabbit jugular vein. Br J Pharmacol. 1989 Dec;98 Suppl:794P. PubMed PMID: 2611511.
8: Hourani SM, Welford LA, Loizou GD, Cusak NJ. Adenosine 5'-(2-fluorodiphosphate) is a selective agonist at P2-purinoceptors mediating relaxation of smooth muscle. Eur J Pharmacol. 1988 Feb 16;147(1):131-6. PubMed PMID: 3371408.
9: Baldo JH, Hansen PE, Shriver JW, Sykes BD. 2-Fluoro-ATP, a fluorinated ATP analog. 19F nuclear magnetic resonance studies of the 2-fluoro-ADP . myosin subfragment-1 complex. Can J Biochem Cell Biol. 1983 Feb-Mar;61(2-3):115-9. PubMed PMID: 6850412.