NSC756093
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 562771

CAS#: 1629908-92-4

Description: NSC756093 is the first inhibitor of the GBP1:PIM1 interaction.

Chemical Structure

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NSC756093
CAS# 1629908-92-4
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 562771
Name: NSC756093
CAS#: 1629908-92-4
Chemical Formula: C20H19NO4
Exact Mass: 337.13
Molecular Weight: 337.375
Elemental Analysis: C, 71.20; H, 5.68; N, 4.15; O, 18.97

Price and Availability

Size Price Availability Quantity
5mg USD 270
25mg USD 640
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Synonym: NSC756093; NSC-756093; NSC 756093;

IUPAC/Chemical Name: 4-(2-Hydroxyethyl)-6-methoxy-9-phenyl-4,9-dihydrofuro[3,4-b]quinolin-1(3H)-one

InChi Key: SMEJQLRLHKWIFV-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H19NO4/c1-24-14-7-8-15-16(11-14)21(9-10-22)17-12-25-20(23)19(17)18(15)13-5-3-2-4-6-13/h2-8,11,18,22H,9-10,12H2,1H3

SMILES Code: O=C1OCC(N2CCO)=C1C(C3=CC=CC=C3)C4=C2C=C(OC)C=C4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Product Data
Instruction:
View handling instruction
Biological target: NSC756093 is a potent inhibitor of the GBP1:PIM1 interaction.
In vitro activity: The inhibition of the GBP1:PIM1 interaction by NSC756093 was dose-dependent (Figure 2B) and statistically significant as compared with the control without drug (p < 0.001, Anova). To confirm the activity of the drug in cell lines, this study assessed the ability of NSC756093 to inhibit the GBP1:PIM1 interaction in SKOV3 cells. Reference: J Med Chem. 2014 Oct 9;57(19):7916-32. https://pubmed.ncbi.nlm.nih.gov/25211704/
In vivo activity: TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 337.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: Andreoli M, Persico M, Kumar A, Orteca N, Kumar V, Pepe A, Mahalingam S, Alegria AE, Petrella L, Sevciunaite L, Camperchioli A, Mariani M, Di Dato A, Novellino E, Scambia G, Malhotra SV, Ferlini C, Fattorusso C. Identification of the first inhibitor of the GBP1:PIM1 interaction. Implications for the development of a new class of anticancer agents against paclitaxel resistant cancer cells. J Med Chem. 2014 Oct 9;57(19):7916-32. doi: 10.1021/jm5009902. Epub 2014 Sep 26. PMID: 25211704; PMCID: PMC4191604.
In vitro protocol: Andreoli M, Persico M, Kumar A, Orteca N, Kumar V, Pepe A, Mahalingam S, Alegria AE, Petrella L, Sevciunaite L, Camperchioli A, Mariani M, Di Dato A, Novellino E, Scambia G, Malhotra SV, Ferlini C, Fattorusso C. Identification of the first inhibitor of the GBP1:PIM1 interaction. Implications for the development of a new class of anticancer agents against paclitaxel resistant cancer cells. J Med Chem. 2014 Oct 9;57(19):7916-32. doi: 10.1021/jm5009902. Epub 2014 Sep 26. PMID: 25211704; PMCID: PMC4191604.
In vivo protocol: TBD

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1: Andreoli M, Persico M, Kumar A, Orteca N, Kumar V, Pepe A, Mahalingam S, Alegria AE, Petrella L, Sevciunaite L, Camperchioli A, Mariani M, Di Dato A, Novellino E, Scambia G, Malhotra SV, Ferlini C, Fattorusso C. Identification of the first inhibitor of the GBP1:PIM1 interaction. Implications for the development of a new class of anticancer agents against paclitaxel resistant cancer cells. J Med Chem. 2014 Oct 9;57(19):7916-32. doi: 10.1021/jm5009902. Epub 2014 Sep 26. PubMed PMID: 25211704; PubMed Central PMCID: PMC4191604.